OBJECTIVES To compare the clinical anesthetic efficacy of 0.5% bupivacaine and 4% articaine (both with 1:200.000 adrenaline) for anterior maxillary infiltration in healthy volunteers. MATERIAL AND METHODS A triple-blind split-mouth randomized clinical trial was carried out in 20 volunteers. A supraperiosteal buccal injection of 0.9 ml of either solution at the apex of the lateral incisor was ...

In recent years worldwide interest has grown towards the development of mucoadhesive drug delivery systems. These systems are capable of adhering to body's mucosal surfaces for an extended period of time, releasing their drug content in a retarded manner. The use of biopolymers, and in particular phytopolymers, could provide a natural basis for the development of such systems. The aim of this s...

In recent years worldwide interest has grown towards the development of mucoadhesive drug delivery systems. These systems are capable of adhering to body's mucosal surfaces for an extended period of time, releasing their drug content in a retarded manner. The use of biopolymers, and in particular phytopolymers, could provide a natural basis for the development of such systems. The aim of this s...

background and objectives: primary acquired nasolacrimal duct obstruction (pando) is a common ocular problem. clinical presentation can range from simple tearing to a life-threatening condition. the exact pathophysiology of obstruction is not completely understood. in this study, therelationship between pando and nasal mucosal goblet cells was investigated.  materials & methods: in this ca...

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

the use of corticosteroids is one of the methods put forward for the strengthening and speeding up the process of labor. after identification of glucocorticoid receptors in human amnion, the role of corticosteroids in starting the process of labor has been studied in numerous studies.the purpose of this study was to determine the effect of intravenous dexamethasone on preparing the cervix and o...

OBJECTIVES The aim of this study was to analyze the clinical efficacy and cytomorphologic changes of colon mucosa following the treatment of patients suffering from irritable bowel syndrome (IBS) with mesalazine (5-aminosalicylic acid [5-ASA]). METHODS In this controlled, randomized, blind clinical trial, a total of 360 patients with varying subtypes of IBS were randomly treated with 500 mg o...

conclusions our data has provided baseline information about epidemiologic aspects of oral mucosal lesions which can be valuable in organized national program targeting on oral health and hygiene in the society. results the prevalence of mucosal lesions in our study was 19.4%. our data demonstrated higher prevalence of oral mucosal lesions in males and young adults (30-40 years). the most commo...

The present study is an investigation of the effects of 12- to 96-hours' starvation and 96-hours' starvation plus 48-hours' refeeding on both somatostatin-like immunoreactivity (SLI) and cytosolic somatostatin binding sites in rabbit small intestinal mucosa. The SLI concentration increased after 24 h in duodenal and jejunal mucosa, but not in ileal mucosa, and reached its highest value after 96...

giant cell fibroma (gcf) was described as a new entity of fibrous hyperplastic soft tissue. it seems that stimulus from an unexplained origin can have a role in its etiology. histopathologically gcf is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. surgical excision is the treatment of choice and recurrence is very rare. here we report a c...