Abnormalities of duodenal motility have been described in patients with duodenal ulcer and in experimental ulcers in rats and it has been postulated that they could be pathogenic in peptic ulcer disease. We have investigated with an isotopic technique whether duodenal bulb clearance or duodenal transit are abnormal in duodenal ulcer. Six patients with inactive and six with active duodenal ulcer...

BACKGROUND Helicobacter pylori is known to be a cause of active chronic gastritis and has been proposed as an etiologic factor in the development of peptic ulcer disease, but controversy continues regarding the pathogenic importance and mechanism. We examined the prevalence of H. pylori infection in patients with peptic ulcers and non-ulcer dyspepsia. METHOD 749 patients (373 with duodenal ul...

STUDY OBJECTIVE The aim was to estimate the age and sex specific incidences of duodenal and gastric ulcers censored for death and migration. DESIGN A population based cohort was followed seven years through records of x ray examinations, endoscopies, and operations in the only hospital serving the area. SETTING The study was conducted in the municipality of Tromsø, Northern Norway, where al...

research advances during recent years offer new insight into therapy and the prevention of gastrointestinal ulcers by using medicinal plants. flavonoids, tannins, triterpenoids, fatty acids and essential oils are among the most effective herbal constituents that have potential antiulcerogenic properties, and most of them could be found in zataria multiflora. z. multiflora is one of the indigeno...

Both KB-5492, a new anti-ulcer agent, and cimetidine, administered orally at 25-200 mg/kg, dose-dependently prevented cysteamine (400 mg/kg, s.c.)-induced duodenal ulcers in rats with ED50 values of 63 and 40 mg/kg, respectively. Anti-ulcer doses of cimetidine, but not KB-5492, inhibited gastric acid hypersecretion induced by cysteamine (400 mg/kg, s.c.). In contrast, anti-ulcer doses of KB-549...

AIMS To determine the gastric distribution of Helicobacter pylori in patients with duodenal and gastric ulcers; and to examine the mucosal inflammatory response. METHODS Patients with newly diagnosed, uncomplicated duodenal and gastric ulcers were endoscoped and two biopsy specimens each taken from the antrum and the body. Specimens were evaluated blind by one pathologist to determine H pylor...