Prevalence of helicobacter pylori was evaluated by urease test in 513 patients undergoing GI endoscopy, in hospital No1 Kerman university of medical sciences and health services from June 1992 through April 1993. H. Pylori was detected in 56.9℅ of tested samples by urease test. There was no significant correlation with sex, age and cigarette smoking. Prevalence of H.pylori was 16℅ in control gr...

Tobacco smoking delays healing of gastric ulcer and may influence duodenal ulceration. Seventy men, all cigarette smokers, were found to have duodenal ulceration at endoscopy. All were advised to stop smoking and received a three-month course of cimetidine. Endoscopy was repeated at three months (n = 63) and at six months (n = 56). At three months most (79%) patients showed ulcer healing and th...

BACKGROUND Helicobacter-pylori-related duodenal ulcer (DU) is an important cause of dyspepsia. AIM To determine the relationship between the pattern of H. pylori infection and the epidemiology of duodenal ulcer in a single population. DESIGN Prospective two-part study of (i) patients with DU referred for endoscopy because of dyspepsia, and (ii) the incidence of H. pylori infection in the ge...

It has long been established that various human body secretions like saliva, semen, gastric juice contain blood group antigens. The individuals whose body fluids other than blood contain blood group antigens are known as secretors whereas the rest are nonsecretors. The secretor status of an individual is a genetically controlled factor. The role of genetic factors in the pathogenesis of duodena...

Duodenal ulceration is a chronic disease the causes of which remain unknown. Current medical treatment interrupts the natural history and accelerates ulcer healing. It does not cure ulcers. All duodenal ulcers are generally considered together even though pathophysiological mechanisms differ from patient to patient. It should not be surprising that some duodenal ulcer patients respond relativel...

In 10 healthy subjects and 10 duodenal ulcer patients the intestinal phase of gastric acid secretion was studied by intraduodenal infusion of a 10% liver extract meal (pH 7) at 400 ml/h for three hours. A gastroduodenal double lumen tube with two balloons was used to block the pylorus and to prevent duodenogastric reflux. Gastric acid response to a duodenal meal of liver extract reached a peak ...

Gastric mucosal phospholipids, and in particular those of the surface layer, play an important part in mucosal barrier function. This study examined whether the phospholipid composition of the full thickness gastric mucosa is changed in peptic ulcer disease and gastritis. The phospholipid composition of gastric mucosa from endoscopic biopsy specimens in 28 subjects (eight healthy controls, 12 p...

BACKGROUND Helicobacter pylori infection of the gastric mucosa is vital in the pathogenesis of duodenal ulcer disease. H pylori will only colonise gastric epithelium and its association with duodenal disease is therefore not easily explained. AIMS To determine if gastric metaplasia in the duodenum increases the risk of duodenal ulcer disease in children infected with H pylori. PATIENTS All ...

The effect of bombesin, a possible neurotransmitter of gastrin release, upon gastrin and gastric acid secretion was investigated in 25 patients with duodenal ulcer and in 16 normal subjects. In patients with duodenal ulcer bombesin (10 ng/kg/min) produced an increase in plasma gastrin output (median 22.4 (range 7.5-75.8) pmol/l/min) similar to that obtained in normal subjects (median 24.4 (rang...

In normal, duodenal ulcer, and gastric ulcer subjects the two main forms of gastrin, G17 and G34, were estimated by radioimmunoassay in fasting serum and after feeding. Two antisera were used: one showing high specificity for G17, the other specific for the common COOH-terminus of G17 and G34 and so allowing estimation of G34 by difference. Basal G17 was similar in gastric ulcer, duodenal ulcer...