OBJECTIVE Duloxetine hydrochloride is a selective serotonin (5-hydroxytryptamine) and norepinephrine reuptake inhibitor. It is approved for effective treatment for major depressive disorder. The pharmacokinetics (PK) of duloxetine has been studied, but few pharmacokinetics properties in Chinese subjects are available. This study explored the dose proportionality and determined duloxetine levels...

Retraction This manuscript [1] has been retracted for inappropriate and unattributed text duplication from a previous paper published in Drug Testing and Analysis [2]. References 1. Alarfaj NA, Ammar RA, El-Tohamy MF: Disposable screen-printed sensors for determination of duloxetine hydrochloride. Chem Central J 2012, 6:6. A: Seleim: Towards disposable sensors for drug quality control: Dextrome...

abstract background: diabetic neuropathy is the most common micro-vascular complications of diabetes. the drugs including gabapentin and duloxetine are often used for the treatment of pain associated with diabetic neuropathy. this study aimed to compare the efficacy of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathy. materials and methods: totally, 34 patients aged ...

To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In all, 150 patients were enrolled and 126 patients completed the study (41 patien...

IMPORTANCE Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations. OBJECTIVE To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population. DESIG...