Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligand interaction will be very important for structure based drug design. Lack of knowledge of 3D structures has hindered efforts to understand the binding specificities of ligands with protein. With increasi...

We define a notion of cosheaves on diffeological spaces by cosheaves on the site of plots. This provides a framework to describe diffeological objects such as internal tangent bundles, the Poincar'{e} groupoids, and furthermore, homology theories such as cubic homology in diffeology by the language of cosheaves. We show that every cosheaf on a diffeological space induces a cosheaf in terms of t...

background: no data is available on morphology and genetic characteristics of echinococcus granulosus derived from donkeys of iran, despite of its existence in donkeys.in the present study morphometric variations of the rostellar hooks of protoscoleces and genotype characteristics of hydatid cyst of donkey from iran were determined. methods: protoscoleces prepared from hydatid cyst of donkey of...

In the current era of modern drug design & development via computer-aided design, potential role computational software tools is widely enlarged in use. Computer-based revolutionary new discovery process because these processes are fast, time, and cost-saving with more efficient pharmacological activity. Computer-Based mainly applied for drug-design gets many successes research. There plent...

As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this con...

we investigate the relative cohomology and relative homology theories of $f$-gorenstein modules, consider the relations between classical and $f$-gorenstein (co)homology theories.

To increase understanding of drug-resistant Vibrio cholerae, we studied selected molecular mechanisms of antimicrobial drug resistance in the 2010 Haiti V. cholerae outbreak strain. Most resistance resulted from acquired genes located on an integrating conjugative element showing high homology to an integrating conjugative element identified in a V. cholerae isolate from India.

background: accurate identification of sheep nematodes is a critical point in epidemiological studies and monitoring of drug resistance in flocks. however, due to a close morphological similarity between the eggs and larval stages of many of these nematodes,such identification is not a trivial task. there are a number of studies showing that molecular targets in ribosomal dna (internal transcri...

Many structurally and therapeutically diverse drugs interact with the human heart K+ channel hERG by binding within the K+ permeation pathway of the open channel, leading to drug-induced 'long QT syndrome'. Drug binding to hERG is often stabilized by inactivation gating. In the absence of a crystal structure, hERG pore homology models have been used to characterize drug interactions. Here we as...