Nirmatrelvir is the main component of first oral drug against SARS-CoV-2 called Paxlovid®. Its development from an orally unavailable predecessor through hydrogen bond donors (HBD) replacement highlighted, followed by examination synthetic routes described in original PCT application WO2021/250648. Based on its attributes, nirmatrelvir shows potential to be a game changer treatment.

BACKGROUND For many people infected with the hepatitis C virus (HCV), the route of exposure, risk of transmission, and severity of associated liver disease are unknown. We studied these variables in people who donated blood voluntarily. METHODS Blood donors who tested positive for HCV antibodies on enzyme immunoassay were classified according to whether the results of a confirmatory second-ge...

Q: Why choose laboratory-based oral fluid drug testing? A: Oral fluid testing offers confidential lab-based drug test results from a minimallyinvasive, observed collection. It is excellent at detecting recent drug use because it can screen for drugs in a donor’s system soon after use. By using oral fluid instead of urine drug testing, employers can oversee their donors as they collect their own...

background: iron deficiency and its related anemia, which is the world’s most widespread nutritional deficiency, can be one of the possible consequences of regular blood donation. this research was carried out to compare iron stores in regular blood donors and first-time blood donors in tehran regional blood transfusion center. materials and methods: this study was carried out on 2,149 male blo...

results implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation. conclusions we need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients evidence acquisitions in this process we s...

The safety of healthy peripheral blood stem cell (PBSC) donors receiving recombinant human granulocyte colony-stimulating factor (rhG-CSF) is a topic that has received considerable attention in recent literature.1-3 The short-term adverse events related to both mobilization and collection as well as the problem of long-term safety monitoring have been discussed extensively, although the latter ...

BACKGROUND Genetic variations of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) can affect diagnostic assays and therapeutic interventions. Recent changes in prevalence of subtypes/genotypes and drug/immune-escape variants were characterized by comparing recently infected vs more remotely infected blood donors. METHODS Infected donors were identified ...

BACKGROUND In the living donor liver transplant setting, the preoperative assessment of potential donors is important to ensure the donor safety. OBJECTIVES The aim of this study was to identify causes and costs of living liver-donors rejection in the donation process. MATERIALS AND METHODS From June 2010 to June 2012, all potential living liver donors for 66 liver transplant candidates wer...