Research background. Lactic acid bacteria (LAB) are known to produce folate. However, this ability is highly strain-dependent. Folate synthesis in specific LAB strains affected by the availability of folate, which can be consumed other under certain conditions. Moreover, differences folate capabilities related presence biosynthesis-related genes and regulation pathway. Experimental approach. As...

Cereals and legumes are rich in folate. However, due to the instability of folate, processing digestion can induce significant folate loss. In this paper, bioaccessibility faba bean, oat, rye wheat flours pastes was studied using a static vitro model. Folate depended on food matrices, varying from 42% 67% 40% 123% pastes. Digestion associated with interconversion formyl folates, as well increas...

background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...

background : increased level of serum homocysteine is one of the risk factor of atherosclerosis. its production related in some sulfur amino acids such as methionine. some important cofactors that are involved in metabolic pathways of this amino acid are folate and vitamin b12. we have assessed the status of methionine, folic acid, and vitamin b12 in some coronary atherosclerotic male patients....

background:   the  role of nutrition  in the  progression  of multiple  sclerosis (ms) and  related  complications  such  as fatigue  has been  reported by several studies.  the  aim of this  study  is the  assessment of nutritional  status  and  its relationship with fatigue in multiple sclerosis patients. methods:  this  is  a  cross-sectional study, in which  101 relapsing-remitting ms patie...

background: leber hereditary optic neuropathy (lhon) is an inherited form of bilateral optic atrophy leading to the loss of central vision.  the primary cause of vision loss is mutation in the mitochondrial dna (mtdna), however, unknown secon­dary genetic and/or epigenetic risk factors are suggested to influence its neuropathology.  in this study folate gene polymor­phisms were examined as a po...

Objective(s): Folate-targeted liposomes have been well considered in folate receptor (FR) overexpressing cells including MCF-7 and 4T1 cells in vitro and in vivo. The objective of this study is to design an optimum folate targeted liposomal formulations which show the best liposome cell uptake to tumor cells.Material and Methods: In this study, we prepared and characterized different targ...