background: the surgical management of cholesteatoma is a controversial issue, particularly regarding intact-canal-wall mastoidectomy (icwm) versus canal-wall-down mastoidectomy (cwdm). the current experiment compared the quality of  visualization in different middle ear structures using icwm with otoendoscopy with findings of cwdm by microscopy.materials and methods: the patients diagnosed wit...

objective: in this study, the possibility of prenatal diagnosis of down syndrome with real-time pcr method was evaluated. in this context, optimization of a suitable method for purification of high quality dna from amniotic fluid samples was also considered. materials and methods: pregnant women who had the high risk of having babies with down syndrome were selected according to the biochemica...

Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors including RB. However, RB treatment by targeting EGFR has not yet been researched. In the current study, we investigated the effect of EGFR down-regula...

introduction: meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. in this article we review some previous techniques and discuss our preferred method. materials and methods: in this observational case series study, we used this technique in 53 patients (28 male and 25 female) between january 2005 and january 2008. our survey was ...

child with down's syndrome is an individual who is suitable and eligible to receive early intervention services. this study aimed to measure the family outcome among parents of down syndrome children, on the impact of receiving early intervention and identify the factors influencing it.a cross sectional was conducted from april 2009 until january 2010 with a total of 125 parents of children wit...

objectives: down syndrome (ds) is the most common multiple congenital anomaly syndrome associated with a developmental disability. children with down syndrome have delay in both motor and mental age. this study carried out to explore relationship between mental and motor age of children with ds. methods: a cross-sectional study was conducted on 60 participants with ds (5 to 7 years old) using r...

introduction: mental retardation, is one of the most common causes for referral to genetic counseling centers, and is one of the greatest challenges in health care services in the world. down syndrome is the most common chromosomal abnormalities in humans. methods: this study performed in medical genetic counseling center of welfare organization in south of iran with high consanguineous marriag...

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