AIM To describe lesions resembling optic disc duplication and highlight their unusual visual fields. The authors also report the first case of pseudo-duplication of the optic disc with overlying retinal nerve fibre layer. METHODS Retrospective, non-comparative review of case notes. Humphrey visual fields and OCT-3 imaging were performed. RESULTS All 11 cases represented peripapillary chorio...

STUDY DESIGN A kinematic analysis of cervical intervertebral disc deformation during simulated whiplash using the whole cervical spine with muscle force replication model was performed. OBJECTIVES To quantify anulus fibrosus fiber strain, disc shear strain, and axial disc deformation in the cervical spine during simulated whiplash. SUMMARY OF BACKGROUND DATA Clinical studies have documented...

Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-mediated apoptosis, yet the mechanisms underlying assembly of this key multiprotein complex remain unclear. Using quantitative mass spectrometry, we have delineated the stoichiometry of the native TRAIL DISC. While current models suggest that core DISC components are present at a ratio of 1:1, our data...

BACKGROUND The origin of the fluid and precise pathophysiology of optic pit maculopathy remain unclear. It has been suggested that submacular fluid originates either from vitreous or cerebrospinal fluid. We report a case of optic pit maculopathy which was unsuccessfully treated with vitrectomy and internal limiting membrane (ILM) peeling, and subsequently resolved with revision of vitrectomy an...

Patients with acute lumbar disc prolapse with sciatica who are not considered candidates for surgery are usually treated with physiotherapy and non-steroidal anti-inflammatory agents. Moreover, the treatment with benzodiazepines is common practice in the absence of class I or II level of evidence. Here we assessed the role of benzodiazepines in the conservative management of acute lumbar disc p...

Double-roll rotary forging is an emerging plastic forming technology based on forging. Owing to the advantages of labor saving, small eccentric load, low noise and vibration, good uniformity, high surface quality, material it very promising for fabrication large-diameter thin-walled disc. To date, a few relevant researches double-roll metal discs have been reported, mechanisms process disc work...

Unlike most double-disc grinding processes, which use forced workpiece rotation, some processes rely on self-rotation driven by non-uniform shear forces resulting from partial wheel-workpiece coverage. This is poorly understood, with angular frequency remaining unknown despite its importance. paper investigates the kinematics of via analytical modelling moment-equilibrium conditions, derived ex...

Degeneration of the lumbar intervertebral disc is a common cause of low back pain and leg pain that affects the physical and mental health of the patient and increases the social burden. This study was performed to observe the biological effects of adeno-associated virus (AAV)-mediated osteogenic protein-1 (OP1) and SOX9 double gene co-transfection in rabbit intervertebral disc degeneration in ...