Doublecortin-like (DCL) is a microtubule-binding protein crucial for neuroblastoma (NB) cell proliferation. We have investigated whether the anti-proliferative effect of DCL knockdown is linked to reduced mitochondrial activity. We found a delay in tumor development after DCL knockdown in vivo in doxycycline-inducible NB tumor xenografts. To understand the mechanisms underlying this tumor growt...

abstract background: the loop colostomy is one of the most popular techniques used as a protective maneuver for a distal anastomosis and/or temporary fecal diversion. we are introducing the use of a full thickness skin bridge under the large bowel instead of a glass rod which alleviates problems such as protrusion of the large bowel, retraction of the bowel into the abdomen after removing the r...

In neuronal cells, activated glucocorticoid receptor (GR) translocates to the nucleus guided by the cytoskeleton. However, the detailed mechanisms underlying GR translocation remain unclear. Using gain and loss of function studies, we report here for the first time that the microtubule-associated protein doublecortin-like (DCL) controls GR translocation to the nucleus. DCL overexpression in COS...

The defective chloroplasts and leaves-mutable (dcl-m) mutation of tomato was identified in a Ds mutagenesis screen. This unstable mutation affects both chloroplast development and palisade cell morphogenesis in leaves. Mutant plants are clonally variegated as a result of somatic excision of Ds and have albino leaves with green sectors. Leaf midribs and stems are light green with sectors of dark...

In plants, RNA silencing-based antiviral defense is mediated by Dicer-like (DCL) proteins producing short interfering (si)RNAs. In Arabidopsis infected with the bipartite circular DNA geminivirus Cabbage leaf curl virus (CaLCuV), four distinct DCLs produce 21, 22 and 24 nt viral siRNAs. Using deep sequencing and blot hybridization, we found that viral siRNAs of each size-class densely cover the...

La fragmentación del sueño puede asociarse con distintas enfermedades, entre ellas, la demencia. En este sentido, de sueño, indicada por el índice alertamientos y/o movimientos periódicos las piernas (MPP), podría ser un marcador temprano deterioro cognitivo leve (DCL), síndrome precursor El objetivo presente estudio fue medir prevalencia los y MPP durante en grupo control DCL, así como determi...

although lcl filters are used widely in the grid connected inverters to reduce high-orderharmonics, such a system increases system order and therefore sustainable design of closed-loopcontroller system will be complicated. recently, the single-loop control strategy has beensuggested for l or lc filter based grid-connected inverters. however, the use of single-loopcontrol directly in lcl filter-...

Using a classical ensemble method, nonsequential double ionization is predicted to exist with elliptical and circular polarization. Recollision is found to be the underlying mechanism, and it is only possible via elliptical trajectories.

A dynamic combinatorial library (DCL) screening approach is described that permits direct identification of the effective (from ineffective) combination of building blocks in the equilibrating DCL. The approach uses Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) together with sustained off-resonance irradiation collision activated dissociation (SORI-CAD) to detect noncov...