The present study was conducted to investigate the possible anxiolytic and sedative ofan acute administration and 4-day repeated dosing of an aqueous extract of flowers of Alceaaucheri (Boiss.) Alef. (EFA) in rats subjected to the elevated plus-maze (EPM), open-field, andhorizontal wire tests. All drugs were administered intraperitoneally. Phytochemical screeningconfirmed the presence of phenol...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...

Michelle Aldrich (left) As VAlerie corrAl of WAMM writes out a dosing regimen for using cannabis oil as a treatment for lung cancer. Aldrich’s remarkable first-person story starts on page 18. continued on page 15 By Fred Gardner Increasing numbers of people have been using Cannabis “oil” —plant extracts consisting of 50% or more THC and/ or CBD— to treat conditions ranging from mild rashes to p...

gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. gentamicin is active against the majority of aerobic gram-negative bacilli such as pseudomonas, klebsiella and escherichia coli. the gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. the monitoring of gentamici...

the purpose of this study was to determine the number of prescribed antibiotics being appropriately adjusted and to assess antibiotics with the highest incorrect dosing based on the patient’s renal function according to distinguished guidelines. the study was conducted at a 446-bed university hospital. one hundred and fifty patients admitted through different wards of the hospital were included...

Metastatic breast cancer (MBC) is almost always incurable, and the median survival is of the order on 18-24 months. Combination therapy with adriamycin (ADR) and docetaxel (DOC) is more effective against MBC than the previous therapy due to differences between their mechanisms. However, the combination of ADR and DOC induces severe adverse effects, limiting its clinical use in many patients wit...