In High Dose Rate (HDR) brachytherapy the conventional dose optimization algorithms consider the multiple objectives in form of an aggregate function which combines individual objectives into a single utility value. As a result, the optimization problem becomes single objective, prior to optimization. Up to 300 parameters must be optimized satisfying objectives which are often competing. We use...

INTRODUCTION The efficacy of radiation therapy treatments for pancreatic cancer is compromised by abdominal motion which limits the spatial accuracy for dose delivery - especially for particles. In this work we investigate the potential of worst case optimization for interfractional offline motion mitigation in carbon ion treatments of pancreatic cancer. METHODS We implement a worst case opti...

IntroductionA fine balance of image quality and radiation dose can be achieved by optimization to minimize stochastic and deterministic effects. This study aimed in ensuring that images of acceptable quality for common radiographic examinations in digital imaging were produced without causing harmful effects. Materials and MethodsThe study was conducted in three phases. The pre-optimization inv...

HDR brachytherapy treatment planning often involves optimization methods to calculate the dwell times and dwell positions of the radioactive source along specified afterloading catheters. The purpose of this study is to compare the dose distribution obtained with geometric optimization (GO) and volume optimization (VO) combined with isodose reshaping. This is a retrospective study of 10 cervix ...

PURPOSE The purpose of this work is to apply a novel inverse optimization approach, based on utilization of quantitative imaging information in the optimization function, to prostate carcinoma. MATERIALS AND METHODS This new inverse optimization algorithm relies upon quantitative information derived from computed tomography (CT) imaging studies. The Hounsfield numbers of the CT voxels are con...

Introduction: The rapid use of computed tomography (CT) scan is of great concern, due to increase in patients’ dose. Optimization of CT protocol is a vital issue in dose reduction. This study aimed to optimize radiation dose in cranial CT and assess modifications in image quality under radiation dose reduction. Material and Methods: A poly(me...