Background: Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. Among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. Material and Methods: In this study...

Introduction: Radiation therapy is an important procedure for treatment of more than half of tumors. One way to increase the efficiency of radiation therapy is application of radiosensitizer at the site of tumor. gold nanoparticles (GNPs) have several characteristics that make them attractive for using with radiation therapy including small size (1–100 nm), biocompatibility, pr...

Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was use...

PURPOSE Recent studies show promise that administering gold nanoparticles (GNP) to tumor cells during brachytherapy could significantly enhance radiation damage to the tumor. A new strategy proposed for sustained administration of the GNP in prostate tumors is to load them into routinely used brachytherapy spacers for customizable in situ release after implantation. This in silico study investi...

High atomic number nanoparticles are of increasing interest in radiotherapy due to their significant positive impact on the local dose applied treatment site. In this work, three types metal were utilized investigate enhancement based GATE Monte Carlo simulation tool. Gold, gadolinium, and silver implanted at different concentrations a 1 cm radius sphere mimic cancerous tumor inside 10 × 30 cm3...

Background: New treatment modali es are developed with the aim of escala ng tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibili es including destroying cancer tumors with minimal damage to healthy ssues. Zinc Oxide nanopar cles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on increa...

PURPOSE High atomic number (Z) materials have been considered as a method for enhancing radiation dose in tumors. The dose enhancement due to interactions of kilovoltage x-rays with high-Z materials (i.e., gold or iodine) has been well demonstrated through computational works. This study is to experimentally quantify the effect using gold nanoparticles (AuNPs) and iodine solutions, respectively...

introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

Introduction: Secondary radiation such as photoelectrons, Auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external X-ray beam after being loaded with elements capable of activating the tumor, e.g.; I and Gd. Materials and Methods:  In this investigation, the MCNPX code was used for simulation and calculation of dose enhancement facto...

Background: Normoxic type MAGICA gel dosimeters are established for dose quantification in three dimensions for radiotherapy. Objective(s): The ability of MAGICA polymer gel was assessed by experimental measurements method for studying the effect of gold nanoparticles (GNPs) in dose enhancement under the external 18MV radiotherapy practices. <...