OBJECTIVE Evidences from clinical trials had demonstrated that statins reduce the risk of cardio-cerebral vascular events. But lipid lowering therapy (LLT) was suboptimal in stroke patients and clinically, observation of reducing the dosage of statins is common when target low density lipoprotein cholesterol (LDL-C) level achieved. We aim to explore the changes in lipid profile after reducing s...

One of the key issues in crop protection products to be applied in tree crops is the dose rate adjustment. An inappropriate dose selection could be responsible of the lack of efficacy due to under dosage and a loss in efficiency due to over dosage. Both situations imply economical losses and greater impacts on the environment. A better dose adjustment is possible from a variable rate technology...

The purpose of this study was to determine the number of prescribed antibiotics being appropriately adjusted and to assess antibiotics with the highest incorrect dosing based on the patient's renal function according to distinguished guidelines. The study was conducted at a 446-bed university hospital. One hundred and fifty patients admitted through different wards of the hospital were included...

OBJECTIVES The prevalence of kidney disease (KD) indicators together with the profile of RA drugs prescribed in RA patients was investigated in the MATRIX study (MeThotreXate And Renal Insufficiency). METHODS Renal function (RF) was assessed using Cockcroft-Gault (CG) and abbreviated Modification of Diet in Renal Disease (aMDRD) study formulae. RESULTS Serum creatinine (SCr) was normal in 8...

OBJECTIVE To compare advice on dosage adjustment for renal impairment provided by four commonly used secondary pharmacotherapeutic sources. DESIGN Systematic comparison of the definitions of renal impairment, recommendations for dosage adjustment, and the evidence in support of these recommendations in four information sources. DATA SOURCES British National Formulary, Martindale: the Comple...

We are proposing the first widely applicable spectrophotometric method, after minimal pretreatment, for irinotecan quantification in plasma, to guide personalized dose adjustment and quality control of bulk or injection dosage.