Only a small number of promising drugs target pancreatic cancer, which is the fourth leading cause of cancer deaths with a 5-year survival of less than 5%. Our goal is to develop a new biotherapeutic agent in which a lysosomal protein (saposin C, SapC) and a phospholipid (dioleoylphosphatidylserine, DOPS) are assembled into nanovesicles (SapC-DOPS) for treating pancreatic cancer. A distinguishi...

PURPOSE The efficacy and sufficiency of a healthcare system is directly related to the knowledge and skills of graduates working in the system. In this regard, many different assessment methods have been proposed to evaluate various skills of the learners. Video Observation of Procedural Skills (VOPS) is one newly-proposed method. In this study we aimed to compare the results of the VOPS method...

BACKGROUND AND PURPOSE L-Threo-3,4-dihydroxyphenylserine (DOPS) is reported to increase the nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells, and this effect is not blocked by treatment with decarboxylase inhibitor. NGF is suggested to play an important role in neuronal survival and regeneration under pathological conditions. We evaluated the possible pr...

We investigated by means of an automated ellipsometer the calcium-dependent binding of prothrombin from a buffer solution to monolayers of dioleoylphosphatidylserine (DOPS) and dioleoylphosphatidylcholine (DOPC) deposited on chromium slides. This technique allows direct measurements of bound and free protein concentrations and is not hampered by calcium-induced aggregation of vesicles. For pure...

This demonstration provides a “hands on” experience to the “internals” of Pergamos, the University of Athens DL System. Pergamos provides uniform high level DL services, such as collection management, web based cataloguing, browsing, batch ingestion and automatic content conversions that adapt to the underlying digital object type-specific specialities through the use of Digital Object Prototyp...

Solving discrete optimization problems (DOP) can be a rather hard task. Many real DOPs contain a huge number of variables and/or constraints that make the models intractable for currently available solvers. There are few approaches for solving DOPs: tree search approaches (e.g., branch and bound), relaxation and decomposition methods. Large DOPs can be solved due to their special structure. Amo...

Many distributed systems (task scheduling, moving priorities, changing mobile environments, ...) can be linked as Dynamic Optimization Problems (DOPs), since they require to pursue an optimal value that changes over time. Consequently, we have focused on the utilization of Distributed Genetic Algorithms (dGAs), one of the domains still to be investigated for DOPs. A dGA essentially decentralize...

Efficient resource management is a great concern for many enterprise developers. One of the most important resources that should be carefully managed is the amount of memory consumed by applications. This paper proposes a novel distributed memory management framework, namely Distributed Object Pool Service (DOPS) which efficiently manages the lifecycle of entity objects in distributed systems. ...

BACKGROUND L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catecholaminergic neurons. Based on the observation of increasing plasma DOPAL after oral administration o...

As research progresses toward understanding the role of the amyloid-beta (Abeta) peptide in Alzheimer's disease, certain aspects of the aggregation process for Abeta are still not clear. In particular, the accepted constitution of toxic aggregates in neurons has shifted toward small oligomers. However, the process of forming these oligomers in cells is also not full clear. Even more interesting...