Following a spinal injury, lampreys at first are paralyzed below the level of transection. However, they recover locomotion after several weeks, and this is accompanied by the regeneration of descending axons from the brain and the production of new neurons in the spinal cord. Here, we aimed to analyse the changes in the dopaminergic system of the sea lamprey after a complete spinal transection...

morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (oit), the exact mechanism has not yet been identified. on this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of tra...

Manganese is a trace element with important involvement in the central nervous system functioning. The effects of manganese excess on central dopaminergic system in case of both basal nuclei and reward system are linked to important pathologic states such as Parkinsonism and cognitive impairment. Our data show that Mn2+ reduces the intensity of experimental morphine addiction in rats (manganese...

For decades, it has been suggested that dysfunction of dopaminergic pathways and their associated modulations in dopamine levels play a major role in the pathogenesis of neurological disorders. Dopaminergic system is involved in the stress response, and the neural mechanisms involved in stress are important for current research, but the recent and past data on the stress response by dopaminergi...

Dopaminergic neuronal circuits underlying self-injurious behavior (SIB) were investigated in neonatal 6-hydroxydopamine (6-OHDA)-induced dopamine-depleted rats. The extent of damaged dopamine neuronal areas was investigated by quantitative analysis of tyrosine hydroxylase (TH) immunocytochemistry and the biochemical quantification of dopamine levels in three groups; neonatal 6-OHDA-treated rats...