background : we aimed to compare hemodynamic and endocrine alterations caused by stress response due to proseal laryngeal mask airway and endotracheal tube usage in laparoscopic cholecystectomy. methods : sixty-three asa i-ii patients scheduled for elective laparoscopic cholecystectomy were included in the study. patients were randomly allocated into two groups of endotracheal tube and proseal ...

Application of the Falck & Hillarp histochemical technique to the rabbit carotid bodyreveals three fluorescent structures: brilliantly fluorescent Type I cells, varicose perivascular nerves, and weakly fluorescent non-varicose fibres. The Type I cell fluorescence is similar to that of a dopamine model system and has the appropriate activation and emission maxima. A catecholamine, identified as ...

A number of double-blind, randomized, controlled trials have confirmed the clinical efficacy of aripiprazole in bipolar disorder and schizophrenia. Aripiprazole is the prototype of the ‘third generation’ atypical antipsychotics, or dopamine-serotoninstabilizers and is characterized by a relatively low risk of inducing metabolic adverse effects, causing sedation and other side effects such as hy...

In the study which was prepared based on factors that can take place in essential hypertension pathology; We aimed to investigate interactions of intensive exercise, high salt and partial NOS inhibition applications with each other, effects water-salt balance blood pressure, changes intrarenal dopaminergic system, is an important natriuretic participation oxidative stress. The rats were given e...

Dopamine and dobutamine are often infused together into acutely ill patients requiring temporary support of cardiac and renal function, but whether these catecholamines affect the metabolic clearance of each other is not established. We determined the kinetics of dopamine and dobutamine as substrates and inhibitors of each other, i.e., apparent V(max), K(m), and K(i), with crude preparations of...

The development of successful pharmacotherapeutics for the treatment of alcoholism is predicated upon understanding the biological action of alcohol. A limitation of the alcohol research field has been examining the effects of alcohol only and ignoring the multiple biological active metabolites of alcohol. The concept that alcohol is a "pro-drug" is not new. Alcohol is readily metabolized to ac...

PERSPECTIVE Ghrelin is the metabolic link connecting calorie restriction to neuroprotection Parkinson's disease (PD) is the second most common neu-rodegenerative disease whereby the number of diagnosed patients rises by 3–4% each year creating an ever-expanding social, medical and financial burden. Symptoms such as rigidity, postural instability and bradykinesia are due to diminished levels of ...

BACKGROUND Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction. It is unknown whether insulin sensitivity is related to endogenous dopamine levels in the ventral striatum of humans. We examined this using the agonist dopamine D2/3 receptor radiotracer [(11)C]-(+...

An analysis of the role of adrenergic transmission in mediating the hyperpolarizing, slow inhibitory postsynaptic potential has revealed that dopamine is apparently the specific synaptic transmitter for this response. An additional action of dopamine was discovered, namely the selective facilitation of another synaptic response, the slow excitatory postsynaptic potential. (This potential is a d...