OBJECTIVE Therapeutic options for Parkinson's disease mainly consist of L-dopa and dopamine agonists. However, in Japan, the product labeling of the ergot dopamine agonists, cabergoline and pergolide, was revised in April 2007 due to the risk of developing cardiac valvulopathy. Here, we describe the prescribing trends of anti-Parkinson drugs from 2005 through 2010 in Japan, and examined whether...

Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen of rat brain. Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 muM dopamine at micromolar concentrations. Among 14 other structurally ...

l-tyrosine, b6 and folic acid are involved in biosynthesis of dopa and consequently dopamine. the aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. a significant decrease in m...

L-tyrosine, B6 and folic acid are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in m...

Apomorphine is a potent dopamine receptor agonist which has been used as a neuro-protective agent in the treatment of Parkinson's disease. SCH-23390 is a synthetic compound that presents selective D1 dopamine receptors antagonist activity and possesses pharmacologic effects similar to standard antipsychotics. Aim: Experimental researches on the effects of two substances acting on dopamine recep...

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neurological and psychiatric disorder...

1 Increases in renal blood flow were produced by intra-arterial injections of dopamine (5-50 mug) in anaesthetized dogs pretreated with alpha- and beta-adrenoceptor antagonists.2 Intra-arterial administration of ergometrine (0.5 mg) or apomorphine (1 mg) produced a depression of the renal dilator responses to dopamine, without affecting renal dilatations in response to intra-arterial acetylchol...

In clinical applications for cancer treatment, chemotherapy coupled with thermotherapy is highly considered. The development of multifunctional nanocomposite materials an appealing strategy use in various including biomedical applications. We present the preparation dopamine-modified mesoporous silica material, which magnetic iron oxide nanoparticles (FeNP) were grown onto outer surface via com...