Oxidative drug metabolism via the cytochrome P450 (CYP) system is a principle means of drug clearance. Several decades of studies have pointed to five CYP forms—CYP1A2, 2C9, 2C19, 2D6, and 3A—as those which are primarily responsible for human metabolism of small molecule (MW <1500) drugs and drug-like compounds.1 The absolute levels and CYP enzyme activities vary substantially among individual ...

BACKGROUND The maximal number of live births (k) per donor was usually determined by cultural and social perspective. It was rarely decided on the basis of scientific evidence or discussed from mathematical or probabilistic viewpoint. METHODS AND RESULTS To recommend a value for k, we propose three criteria to evaluate its impact on consanguinity and disease incidence due to artificial insemi...

In this work, we have studied the miniband and minigaps of GaN/AlN constant total effective radius multi-shells quantum dots (CTER-MSQDs) and Rings (CTERMSQRs).We have investigated effects of the Hydrogenic donor impurities, quantum dots and rings radii, and the number of wells on miniband formation by sub-band energy calculations. We show that in these systems, minigaps can be created and then...

selective deficiency of immunoglobulin a (iga) is the most frequent primary hypogammaglobulinemia. as some iga-deficient patients have iga antibodies in their plasma which may cause anaphylactic reactions, blood centers usually maintain a list of iga-deficient blood donors to prepare compatible blood components. in this study we determined the incidence of selective iga deficiency (sigad) in no...

in the september and november 2006 issues of nature clinical practice nephrology , two articles regarding living unrelated kidney donor transplantation alluded to the practices in iran. having served in the planning, supervision and implementation of various aspects of health care in iran, including organ transplantation (anh), and as transplant nephrologists who have actively participated in t...

Background: Nowadays, gamete and embryo donation is applied as effective process in treatment infertility problems. In order to participate in the process of donation, donors should complete an extensive questionnaire that details their personal and family medical history. Included in this questionnaire should be a detailed sexual history, substance abuse history, history of family disease, and...

brain death is defined as the permanent, irreversible and concurrent loss of all brain and brain stem functions. brain death diagnosis is based on clinical criteria and it is not routine to use paraclinical studies. in some countries, electroencephalogram (eeg) is performed in all patients for the determination of brain death while there is some skepticism in relying on eeg as a confirmatory te...