نتایج جستجو برای: dna mitochondrial

تعداد نتایج: 613263  

Mitochondria are membrane-enclosed organelle found in most eukaryotic cells, which known as power house in cells. This organelle transforms energy into forms that are usable by the cell. The most common psychiatric disorders such as depression and anxiety can be linked to mitochondrial disorders. Furthermore, mutations of mitochondrial or nuclear DNA (mtDNA and nDNA, respectively) have been lin...

Allahveisi A, Ghaffari Novin M Yousefian E

Background: Mitochondria are the most aboudent and small essential organelles found in eukaryotic cells. These are semiautonomous organelles for the production of cellular ATP that through its various biochemical pathways. The primary pathway for ATP production is OXPHOS via the electron transfer chain (ETC) which is encoded by nuclear DNA and mtdna genomes. Mitochondria consist of double stran...

Journal: :JCI insight 2021

Background. Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.

Journal: :Frontiers in Molecular Medicine 2023

Mutations in the mitochondrial-DNA or mitochondria related nuclear-encoded-DNA lead to various multisystemic disorders collectively termed mitochondrial diseases. One three cases of disease affects heart muscle, which is called cardiomyopathy (MCM) and associated with hypertrophic, dilated, noncompact cardiomyopathy. The an organ high energy demand, occupy 30%–40% its cardiomyocyte-cell volume....

Mitochondria contain their own DNA (mtDNA), which codes for 13 proteins (all subunits of the respiratory chain complexes), 22 tRNAs and 2 rRNAs. Several mtDNA point mutations as well as deletions have been shown to be causative in well-defined mitochondrial disorders. A mixture of mutated and wild type mtDNA (heteroplasmy) is found in most of these disorders. Inheritance of mtDNA is maternal, a...

Journal: :DNA 2023

Transcription factor A, mitochondrial (TFAM) is a key player in DNA (mtDNA) transcription and replication [...]

درویش‌زاده, فرزانه , سلطان‌دراج, قمر , لاریجانی, باقر , هوشمند, مسعود ,

Background: Mitochondria is one of the intracellular organelle with specific DNA. Some diseases caused by mtDNA mutations have been reported up to now. Mutation of A3243G and deletion of 5kb are two of them that related to Diabetes type II. The aim of this study was to evaluate the frequency of A3243G mutation and 5kb mt DNA deletion in type II diabetic patients.Methods: The DNA extracted from...

Journal: :Iranian Journal of Blood and Cancer 2022

The Mitochondrial DNA 4977-bp Deletion in Patients with Colorectal Cancer: a Case-control Study Iran

Dianat T, Heidari MM Khatami M Moshtaghiun M

Background: Varicocele is the abnormal tortuosity and dilatation of the veins of the pampiniform plexus within the spermatic cord. Varicocele-related pathology is suspected in infertility as it leads to elevated temperatures in the scrotum and testes, which has a deleterious effect on spermatogenesis. In Varicocele patients, ROS production is enhanced and total antioxidant capacity (TAC) is red...

Journal: :genetics in the 3rd millennium 0
صدف کسرایی sadaf kasraie national institute of genetic engineering and biotechnology (nigeb), tehran, iran مسعود هوشمند masoud houshmand محمد مهدی بانویی mommad mehdi banoei سولماز اعتماد اهری soolmaz etemad ahari مهدی شفا شریعت پناهی mehdi shafa shariat panahi پوران شریعتی pouran shariati محمد علی بهار

huntington disease (hd) is a genetically dominant condition caused by expanded cag repeats which code for glutamine in the hd gene product, huntingtin. huntingtin is expressed in almost all tissues, so abnormalities outside the brain can also be expected. involvement of nuclei and mitochondria in hd pathophysiology has been suggested. in fact, mitochondrial dysfunction is reported in brains of ...

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