In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or damaged site on DNA. perform this task based diffusion. Nevertheless, investigations over recent decades have found that diffusion dynamics are generally complicated and, further, protein specific. review, we collect experimental and theoretical studies quan...

The nuclear pore complex is a multiprotein comprising approximately 30 different proteins called nucleoporins (Nups). Recent studies in yeast, animals, and plants have shown that the Nups bind to chromatin interact with transcription factors, chromatin-remodeling histone-modifying enzymes, structural proteins, including CCCTC-binding factor cohesin. These findings suggest provide subnuclear pla...

The aim of this work is to present the experimental results in form an algorithm for analyzing modification screen printed electrodes, including possibility its regeneration irreversibly oxidizing biologically active compounds (drugs, DNA and proteins). A protocol was developed quantitative analysis study mechanism drug-DNA interaction by differential pulse voltammetry, following parameters: co...

conclusions this information provides an explanation for the previously valuable literature on the functions of lncrnas and suggest for the novel therapeutic targeting. results the lncrnas hottip, h19, hotair, malat1, antisense igf2r (air), hoxa13, gtl2 (also called meg3) and uc002mb have been reported in association with hcc. besides, this study predicted that eif4aiii, ptb and fus were the mo...

Significance Positive and negative supercoiling refers to the overwinding or underwinding, respectively, of a DNA double helix. Supercoiling is important ubiquitous, as all cells, from bacterial human, deploy proteins keep their genome negatively supercoiled facilitate transcription replication. Additionally, polymerase transcribes gene, its action generates twin domains supercoils opposite sig...