نتایج جستجو برای: dlbcl

تعداد نتایج: 2906  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Javeed Iqbal Paul N Meyer Lynette M Smith Nathalie A Johnson Julie M Vose Timothy C Greiner Joseph M Connors Louis M Staudt Lisa Rimsza Elaine Jaffe Andreas Rosenwald German Ott Jan Delabie Elias Campo Rita M Braziel James R Cook Raymond R Tubbs Randy D Gascoyne James O Armitage Dennis D Weisenburger Wing C Chan

PURPOSE We have previously shown the prognostic significance of BCL2 expression in the activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) patients treated with cyclophosphamide-Adriamycin-vincristine-prednisone (CHOP) or CHOP-like therapy. However, after the inclusion of rituximab (R) in the CHOP regimen, several conflicting observations about the prognostic value of BCL2 expressio...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2001
B Maes A Anastasopoulou J C Kluin-Nelemans I Teodorovic R Achten A Carbone C De Wolf-Peeters

BACKGROUND The EORTC clinical trial 20901, activated in 1990, was designed to treat non-Hodgkin's lymphomas (NHL) of intermediate/high-grade malignancy according to the Working Formulation. Established in 1994, the R.E.A.L. Classification on NHL has now replaced all former classifications. PATIENTS AND METHODS We reanalysed all cases (n = 273) documented by material available for review accor...

Journal: :Blood 2015
Javeed Iqbal Yulei Shen Xin Huang Yanyan Liu Laura Wake Cuiling Liu Karen Deffenbacher Cynthia M Lachel Chao Wang Joseph Rohr Shuangping Guo Lynette M Smith George Wright Sharathkumar Bhagavathi Karen Dybkaer Kai Fu Timothy C Greiner Julie M Vose Elaine Jaffe Lisa Rimsza Andreas Rosenwald German Ott Jan Delabie Elias Campo Rita M Braziel James R Cook Raymond R Tubbs James O Armitage Dennis D Weisenburger Louis M Staudt Randy D Gascoyne Timothy W McKeithan Wing C Chan

We studied the global microRNA (miRNA) expression in diffuse large B-cell lymphoma (DLBCL; n = 79), Burkitt lymphoma (BL; n = 36), primary mediastinal B-cell lymphoma (PMBL; n = 12), B-cell lines (n = 11), and normal subsets of naïve B cells, centroblasts (CBs), and peripheral blood B cells along with their corresponding gene expression profiles (GEPs). The normal B-cell subsets have well-defin...

2018
Yijun Jia Chenbo Sun Zebing Liu Weige Wang Xiaoyan Zhou

Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's lymphoma with limited data. In this study, a population-based study of primary breast DLBCL in the United States was performed to determine its incidence trends, prognostic factors, survival, the role of surgery as well as the comparison with nodal DLBCL. 1021 patients diagnosed with breast DLBCL were identified in the...

Journal: :Experimental and molecular pathology 2003
Lisa Patrone Sarah E Henson Jelena Teodorovic Cindy S Malone Samuel W French Randolph Wall Michael A Teitell

Diffuse large B-cell lymphoma (DLBCL) is more prevalent and more often fatal in AIDS patients compared to immune-competent individuals. Potential explanations for these differences include distinct tumorigenic mechanisms and/or altered cellular microenvironments. We previously discovered that the TCL1 (T-cell leukemia-1) proto-oncogene is expressed in a high proportion of AIDS-DLBCL compared to...

Journal: :Blood 2009
Kieron Dunleavy Stefania Pittaluga Myron S Czuczman Sandeep S Dave George Wright Nicole Grant Margaret Shovlin Elaine S Jaffe John E Janik Louis M Staudt Wyndham H Wilson

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed distinct molecular subtypes that include germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. ABC DLBCL has a worse survival after upfront chemotherapy and is characterized by constitutive activation of the antiapoptotic nuclear factor-kappa B (NF-kappaB) pathway, which can inhibit chemotherapy. ...

2008
Izidore S. Lossos

Diffuse large B-cell lymphoma (DLBCL) it the most common adult Non-Hodgkin’s lymphoma with an annual incidence of more than 25,000 cases in the United States. Although DLBCL has characteristic morphology, marked immunophenotypic, cytogenetic and molecular heterogeneity underlies the variable clinical outcome of DLBCL patients. Consequently, it is expected that clinical surrogates, such as the i...

Journal: :International journal of clinical and experimental medicine 2015
Chongyang Wu Xiangyang Wu Xiaoni Zhang Ye Chai Qi Guo Lijuan Li Lingling Yue Jun Bai Zhiping Wang Liansheng Zhang

OBJECTIVE The revised International Prognostic Index (R-IPI) aids in predicting the prognosis of patients with diffuse large B cell lymphoma (DLBCL), but R-IPI yields no significant differences in assessing different subtypes of DLBCL. It is necessary to identify patients with a high-risk of DLBCL and alternative therapy should be delivered as early as possible. METHODS In total, 144 patients...

Journal: :International journal of clinical and experimental pathology 2013
Jinfeng Zheng Jiagang Xu Shufang Ma Xiyan Sun Ming Geng Lin Wang

We studied the clinicopathological and imaging characteristics of primary central nervous system diffuse large B-cell lymphomas (PCNS-DLBCL). Imaging, pathologic histology, and immunohistochemical staining characteristics were analyzed, and the immunoglobulin heavy and light chain gene rearrangement of 25 PCNS-DLBCL cases was examined. MicroRNA was extracted from 10 cases each of PCNS-DLBCL, ex...

2014
Sally E. Trabucco Rachel M. Gerstein Andrew M. Evens James E. Bradner Leonard D. Shultz Dale L. Greiner Hong Zhang

Purpose: Approximately 50% of patients with diffuse large Bcell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a critical need to identify effective and targeted therapeutics for DLBCL. Experimental Design: Recent studies have highlighted the incidence of increased c-MYC pro...

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