The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs t...

Male albino rats weighing between 150-225 gm fasted over night but freed having water ad libitum were used to assess the diuretic efficacy of intramuscular aminophylline and frusemide separately and concurrently after intraperitoneal 10 ml of distilled water loading. The normal rate of diuretic weight loss was less augmented by aminophylline and more augmented by frusemide. The diuretic respons...

Chronic kidney disease (CKD) is frequently complicated with hyponatremia, probably because of fluid overload or diuretic usage. Hyponatremia in CKD population is associated with increased mortality, but the effect on renal outcome was unknown. We investigated whether hyponatremia is associated with fluid status and is a prognostic indicator for adverse outcomes in a CKD cohort of 4,766 patients...