Disseminated superficial actinic porokeratosis (DSAP) is a disorder of abnormal keratinization for which there no standard treatment. Treatment modalities that have traditionally been utilized with varying success include ablative therapies, topical pharmacologic treatments, surgical excision, and retinoids. The underlying pathophysiology DSAP secondary to genetic mutations in the mevalonate bi...

Disseminated superficial actinic porokeratosis is a rare photodistributed disorder that has occasionally been reported in association with psoriasis. Treatment of psoriasis with phototherapy may trigger the onset of porokeratosis in some cases. In other cases, the coexistence of these disorders may be coincidental. Clinical inspection of lesions of coexisting porokeratosis and psoriasis reveals...

Porokeratosis refers to a group of hereditary or acquired disorders of epidermal keratinization and is characterized histologically by the presence of a cornoid lamella. The clinical variant referred to as disseminated superficial porokeratosis has been described in the literature in association with immunosuppressive conditions that include organ transplant, infections and immunosuppressive tr...