Background. The duration of anti-CMV after LT varies widely among transplant centers. Because CMV is associated with poor outcome, some centers have extended prophylaxis to reduce the rates of CMV disease. We aimed to assess the epidemiology and outcome of CMV infection in high-risk LT recipients receiving extended (and for some, lifelong) prophylaxis. Methods. This is a retrospective review of...

BACKGROUND Cytomegalovirus (CMV), the most common opportunistic viral infection in solid organ transplant recipients, is associated with substantial morbidity and mortality. PURPOSE To assess the efficacy of universal prophylaxis and preemptive approaches in preventing CMV organ disease and other complications in solid organ transplant recipients. DATA SOURCES Using no language restrictions...

BACKGROUND Cytomegalovirus (CMV) disease is a major cause of morbidity and mortality in solid organ transplant patients and is associated with large additional healthcare expenditures. An economic evaluation of valaciclovir CMV prophylaxis in a renal transplant population is reported. METHODS Medical resource use data were collected alongside a multicenter multinational randomized, placebo-co...

OBJECTIVES Cytomegalovirus infections cause the most frequent infection after solid-organ transplant. While Cytomegalovirus prophylaxis is established in high-risk patients (donor+/ recipient-), data on Cytomegalovirus prophylaxis in other serostatus constellation are rare. The aim of this study was to evaluate the influence of Cytomegalovirus treatment strategy after a liver transplant (preemp...

Infective endocarditis is a severe disease with high mortality, and results most often from the combination of bacteraemia (sometimes provoked) and a predisposing cardiac condition. Prophylaxis for infective endocarditis has been recommended by different countries on the basis of the supposed pathophysiology of the disease, although no randomised clinical trial has confirmed its efficacy. We re...

Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of vs. host disease for children young adults undergoing hematopoietic stem cell transplant (HSCT). However, international rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks cohort isolation or food restrictions. Suppor...