Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disease caused by mutations, deletions, or duplications of the proteolipid protein (PLP) gene. Mutant forms of PLP are retained in the endoplasmic reticulum (ER), and the resulting accumulation of mutant protein is thought to be a direct cause of oligodendrocyte cell death, which is the primary clinical feature of PMD. The molecular mechani...

In this paper, we propose a model-based machine-learning approach for dual-polarization systems by parameterizing the split-step Fourier method Manakov-PMD equation. The resulting combines hardware-friendly time-domain nonlinearity mitigation via recently proposed learned digital backpropagation (LDBP) with distributed compensation of polarization-mode dispersion (PMD). We refer to as LDBP-PMD....

Pelizaeus-Merzbacher Disease (PMD) is a rare X-linked recessive leukodystrophy caused by mutations in the proteolipid protein 1 gene on the Xq22 chromosome. PMD is a dysmyelinating disorder characterized by variable clinical presentation and course. Symptoms range from mild motor deficits to progressive spasticity and neurologic decline resulting in death at an early age. There is no definitive...

Pellucid marginal degeneration (PMD) is an uncommon cause of inferior peripheral corneal thinning disorder, characterized by irregular astigmatism. We analyzed a case of bilateral PMD patient and treated one eye with corneal collagen cross-linking (CXL) therapy. Corneal topography was characteristic for PMD. Visual acuity, slitlamp examinations, tonometry, and corneal thickness were observed. S...

BACKGROUND AND PURPOSE Evaluation of posterior circulation with single-gate transcranial Doppler (TCD) is technically challenging and yields lower accuracy parameters in comparison to anterior circulation vessels. Transcranial power motion-mode Doppler (PMD-TCD), in addition to spectral information, simultaneously displays in real-time flow signal intensity and direction over 6 cm of intracrani...

Polarization Mode Dispersion (PMD) is considered to be one of the most serious obstacles in the high speed optical telecommunication systems. This thesis focuses on a deterministic approach to both compensation and emulation of PMD. Most PMD compensation schemes in the literature rely on feedback loops to search for the optimum control parameters in the compensator. These schemes often suffer f...

We describe a method of characterizing high-order polarization mode dispersion (PMD). Using a new expansion to approximate the Jones matrix of a polarization-dispersive medium, we study the length dependence of high-order PMD to the fourth order. A simple rule for the asymptotic behavior of PMD for short and long fibers is found. It is also shown that, in long fibers (~1000 km), at 40 Gbits/s t...

Timing recovery is critical for synchronizing the clocks at transmitting and receiving ends of a digital coherent communication system. The core timing to determine reliably current sampling error local digitizer so that circuit may lock stable operation point. Conventional phase detectors need adapt optical fiber channel common effects this channel, such as chromatic dispersion (CD) polarizati...

BACKGROUND Pelizaeus-Merzbacher disease (PMD) is a rare X-linked recessive neurologic disorder caused by a mutation in the proteolipid protein (PLP) gene on chromosome Xq22. The associated depletion of PLP and severe reduction of other major myelin proteins results in dysmyelination. MRI reveals loss of T1 contrast between gray and affected white matter and T2 hyperintensities of white matter d...

The course of primary myocardial disease (PMD) was observed in 39 alcoholics. After initial examination 3 years or more before this report, we classified the severity of each patient's illness as stage I, II, or III. Stage I patients had minimal symptoms and normal-sized hearts. Stage II patients had evidence of concentric left ventricular hypertrophy and clinical manifestations like those of h...