Recombinant forms of human immunodeficiency virus type 1 (HIV-1) have been shown to be of major importance in the global AIDS pandemic. Viral RNA dimer formation mediated by the dimerization initiation sequence (DIS) is believed to be essential for viral genomic RNA packaging and therefore for RNA recombination. Here, we demonstrate that HIV-1 recombination and replication are not restricted by...

OBJECTIVES The objective was to evaluate the use and utility of a novel set of emergency department discharge instructions (DIs) for concussion based on a child's ongoing symptoms: symptom-guided DIs (symptom DIs). Differences in clinical outcomes were also assessed. METHODS A convenience sample of 114 children aged 7 to 17 years presenting to an urban pediatric emergency department with a co...

BACKGROUND AND OBJECTIVES Alcohol abuse complicates treatment of HIV disease and is linked to poor outcomes. Alcohol pharmacotherapies, including disulfiram (DIS), are infrequently utilized in co-occurring HIV and alcohol use disorders possibly related to concerns about drug interactions between antiretroviral (ARV) medications and DIS. METHOD This pharmacokinetics study (n=40) examined the e...

The Distributed Interactive Simulation (DIS) IEEE-1278.1 standard is used in many military simulations. The binary data format for DIS does not lend itself to use in emerging web services standards or data analysis and storage tools because the data format is not recognized by most general purpose data manipulation tools. We examine an alternate XML-based representation of DIS information. An X...

doctors and clients sometimes experience interactive clashes during hospital meetings in south-western nigerian hospitals because of their divergent culture-constrained orientation to politeness cues. the goal of this paper is to unpack the discursive elements that characterize interactive confluence and divergence in selected consultative encounters in the hospitals. the findings indicate that...