Radiotherapy treatment plan may be replanned due the changes of tumors and organs at risk (OARs) during the treatment. Deformable image registration (DIR) based Computed Tomography (CT) contour propagation in the routine clinical setting is expected to reduce time needed for necessary manual tumors and OARs delineations and increase the efficiency of replanning. In this study, a DIR method was ...

OBJECTIVE To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct postmortem MRI to histopathology comparison. METHODS Single-slab 3D DIR and 3D fluid-attenuated inversion recovery (FLAIR) images of 56 matched fresh brain samples from 14 patients with chronic MS were acquired at 1.5 T. The ...

PURPOSE To quantitatively compare the diagnostic capability of double inversion-recovery (DIR) with F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of seizure focus laterality in temporal lobe epilepsy (TLE). METHODS This study was approved by the institutional review board, and written informed consent was obtained. Fifteen patients with TLE and 38 healthy volunt...

Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strateg...

INTRODUCTION The application of deformable image registration (DIR) to megavoltage computed tomography (MVCT) images benefits adaptive radiotherapy. This study aims to quantify the accuracy of DIR for MVCT images when using different deformation methods assessed in a cubic phantom and nasopharyngeal carcinoma (NPC) patients. METHODS In the control studies, the DIR accuracy in air-tissue and t...

Introduction: Double Inversion Recovery (DIR) [1] is a valuable tool for the diagnosis of cortical and/or sub cortical lesions [2]. By introducing non-selective 3D acquisitions the problem of inherent CSF-inflow artifacts and partial volume effects in DIR images have been reduced, substantially improving the sensitivity and specificity of detecting sub-millimeter lesions . Successful implementa...

BACKGROUND Deformable image registration (DIR) is an attractive method for automatic propagation of regions of interest (ROIs) in adaptive lung radiotherapy. This study investigates DIR for automatic contour propagation in adaptive Non Small Cell Lung Carcinoma patients. METHODS Pre and mid-treatment fan beam 4D-kVCT scans were taken for 17 NSCLC patients. Gross tumour volumes (GTV), nodal-GT...

Introduction Deformable image registration (DIR) is used to modify structures according to anatomical changes for observing the dosimetric effect. In this study, megavoltage computed tomography (MVCT) images were used to generate cumulative doses for nasopharyngeal cancer (NPC) patients by various DIR methods. The performance of the multiple DIR methods was analysed, and the impact of dose accu...

PURPOSE In this work, we propose a new method of calibrating cone beam computed tomography (CBCT) data sets for radiotherapy dose calculation and plan assessment. The motivation for this patient-specific calibration (PSC) method is to develop an efficient, robust, and accurate CBCT calibration process that is less susceptible to deformable image registration (DIR) errors. METHODS Instead of m...

OBJECTIVE Accurate identification and localization of cortical gray matter (CGM) lesions in MS is important when determining their clinical relevance. Double inversion recovery (DIR) scans have been widely used to detect MS CGM lesions. Phase sensitive inversion recovery (PSIR) scans have a higher signal to noise, and can therefore be obtained at a higher resolution within clinically acceptable...