The unfolded protein response (UPR) counteracts stress caused by unprocessed ER client proteins. A genome-wide survey showed impaired induction of many UPR target genes in xbp-1 mutant Caenorhabditis elegans that are unable to signal in the highly conserved IRE1-dependent UPR pathway. However a family of genes, abu (activated in blocked UPR), was induced to higher levels in ER-stressed xbp-1 mu...

Die Normen DIN EN 61508 und DIN EN 62304 beschreiben Sicherheitsanforderungen für die Entwicklung von Software im medizinischen Umfeld. Diese beinhalten u.a. Vorschriften zur Verifikation und Diagnose (Kapitel C5, DIN EN 61508-7 [Di09]), zur Beurteilung der funktionalen Sicherheit (Kapitel C6, DIN EN 61508-7 [Di09]), zur Implementierung und Verifikation von Software-Einheiten (Kapitel 5.5, DIN ...

1 Center for Systems Biology and Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, School of Engineering and Natural Sciences, University of Iceland, Reykjavík, Iceland, 2 Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland, 3 Division of Science and Math, Center for Genomics and Systems Biology, New York University Abu Dhabi Institute, Ne...

BACKGROUND The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource for epidemiological and health services research. GPRD (based on VAMP) presents notes as a series of discrete episodes, whereas DIN is based on a system (MEDITEL) that used a Pr...

Background: The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource for epidemiological and health services research. GPRD (based on VAMP) presents notes as a series of discrete episodes, whereas DIN is based on a system (MEDITEL) that used a P...

Asymptomatic bacteriuria (ABU) is a bacterial carrier state in the urinary tract that resembles commensalism at other mucosal sites. ABU strains often lack the virulence factors that characterize uropathogenic Escherichia coli (E. coli) strains and therefore elicit weak innate immune responses in the urinary tract. In addition, ABU strains are active modifiers of the host environment, which the...

In this study, we evaluated the sink and source of the surface water along the PRE using a mixing model method with salinity as tracer. The observational data showed that the decreasing of dissolved inorganic nitrogen (DIN) did not closely follow the physical mixing lines of freshwater and modified seawater. In the western part, DIN consumption by phytoplankton and bacteria uptake (ΔDIN)varied ...

Cuvinte cheie: alergie, proteine lapte vacă, toleranţa orală Rezumat: Alergia la proteinele din laptele de vacă este definită ca reacţia imunologică, mediată sau nemediată IgE, la proteinele din laptele de vacă. Afectează populaţia pediatrică în primii 2 ani de viaţă, după această vârstă instalându-se toleranţa la proteinele din laptele de vacă. Sistemul imun intestinal este răspunzator de iniţ...

OBJECTIVE The primary objective of the study was to investigate the feasibility, reliability, and validity of the Dutch digits in noise (DIN) test for measuring speech recognition in hearing aid and cochlear implant users and compare results to the standard sentences-in-noise (SIN) test. DESIGN The relation between speech reception thresholds for DIN test and SIN test was analysed to determin...

Input-output budgets for dissolved inorganic nitrogen (DIN) are summarized for 24 small watersheds at 15 locations in the northeastern United States. The study watersheds are completely forested, free of recent physical disturbances, and span a geographical region bounded by West Virginia on the south and west, and Maine on the north and east. Total N budgets are not presented; however, fluxes ...