This study describes the in-silico design, synthesis, and evaluation of a cross-linked PVA hydrogel (CLPH) for the absorption of organophosphorus pesticide dimethoate from aqueous solutions. The crosslinking effectiveness of 14 dicarboxilic acids was evaluated through in-silico studies using semiempirical quantum mechanical calculations. According to the theoretical studies, the nanopore of PVA...

INTRODUCTION Acute self-poisoning with the organophosphorus (OP) pesticide dimethoate has a human case fatality three-fold higher than poisoning with chlorpyrifos despite similar animal toxicity. The typical clinical presentation of severe dimethoate poisoning is quite distinct from that of chlorpyrifos and other OP pesticides: many patients present with hypotension that progresses to shock and...

A bioassay of the carcinogenicity of technical-grade dimethoate was conducted using Osborne-Mendel rats and B6C3F1 mice. The test material was administered in feed to groups of 50 rats of each sex at either of two concentrations for 80 weeks, followed by 35 weeks of observation. Initial doses were not well tolerated; therefore, they were reduced during the study. The "time-weighted average dose...

As part of a project funded by the European Commission (EC) for the development and evaluation of multiresidue methods for analysis of drinking and related waters, 15 European laboratories evaluated a method using styrene-divinylbenzene co-polymer solid-phase extraction followed by gas chromatography/mass spectrometry. The main aim of the study was to evaluate whether the method meets the requi...

The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD50 for 5 consecutive days a...

Static renewal evaluation of the acute toxicity of an organophosphate pesticide, dimethoate against the freshwater fish H. fossilis was conducted in the laboratory. H. fossilis showed behavioural changes against dimethoate intoxication. There were increased opercular movement, sluggish, lethargic and abnormal swimming, loss of buoyancy and muscular tetany. The treated fishes also showed fading ...

The aim of this study was to compare the effect dose prepared from two different stocks in an acute contact toxicity test honeybees, Apis mellifera L under laboratory condition. Dimethoate 30% EC contains active ingredient 90.18 % w/w which used as substance. conducted per OECD Guideline 214 (1998). stock solution 69.92 ppm (Stock I) and 4.3ppm II) were deionized water. evaluated against honeyb...

A study was undertaken to examine the effect of the oral administration of dimethoate and/or pyrantel on the activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and the concentration of malondialdehyde (MDA) in the liver of rats. Dimethoate was administered to the animals at a dose of 38.7 mg/kg b.w. for 5 consecutive days and pyrantel at a dose of 400 mg/kg b.w. for 3 con...

Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue. By contr...