treatment planning that follows thereafter. However, a significant number of transthoracic biopsies to analyse lung lesions give indeterminate results. A group working at the Antoni van Leeuwenhoek hospital in the Netherlands are tackling this problem with the use of biophotonic techniques [1] – namely Diffuse Reflectance Spectroscopy (DRS) and Fluorescence Spectroscopy (FS) – to assess how the...

The applicability of optical spectroscopy for intraoperative detection of brain tumors/tumor margins was investigated in a pilot clinical trial consisting of 26 brain tumor patients. The results of this clinical trial suggest that brain tumors and infiltrating tumor margins (ITM) can be effectively separated from normal brain tissues in vivo using combined autofluorescence and diffuse-reflectan...

Introduction Accurate, rapid and non-invasive detection and diagnosis of malignant disease in tissues is an important goal of biomedical research. Optical methods, such as diffuse reflectance, fluorescence spectroscopy, and Raman spectroscopy, have all been investigated as ways to attain this goal. Diffuse reflectance utilizes the absorption and scattering properties of tissues, particularly fr...