We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severit...

This paper is a case report and literature review. The objective of this article is to address a rather unusual case of central cord syndrome in a patient with diffuse idiopathic skeletal hyperostosis and focal ossification of the posterior longitudinal ligament. We also discuss the mechanism of injury in central cord syndrome, as well as that specific to involvement of diffuse idiopathic skele...

In diffuse idiopathic skeletal hyperostosis (DISH), recurrence of hyperostosis after surgical removal is common. While both non-steroidal anti-inflammatory drugs (NSAIDs) and radiotherapy have been used in the prevention of heterotopic ossification, only NSAIDs have been applied for prophylaxis in DISH. As a previously undescribed prophylaxis of recurrence in DISH, we report a case treated with...