................................................................................................4.1 4.1 EXPERIMENTAL SETUP......................................................................4.2 4.2 AUTOMATED REACTORS...................................................................4.3 4.2.1 One Litre Reactor........................................................................................

Pressure perturbation differential scanning calorimetry was used to determine thermal expansion coefficients and thus temperature-induced volume changes of DNA duplexes differing in their GC/AT content. It was shown that the temperature-induced unfolding of the DNA duplexes proceeds with a significant increase of the thermal expansion coefficient and the partial volume of the DNA. Unusually, la...

Abstract Controlled and targeted drug delivery systems consist of a carrier matrix one or more active ingredients. One the roles is to regulate release drug. Uptake, release, differential scanning microcalorimetry (DSC) powder X-ray diffraction (XRD) techniques were used reveal interactions governing dopamine indole from thermoresponsive model polymer gel. The can be completely recovered loaded...

This paper describes a thermal imaging system which includes a customized micromachined thermal probe and circuit interface for a scanning microscopy instrument. The probe shank is made from polyimide for mechanical compliance and high thermal isolation, and has a thin-film metal tip of ≈50 nm in diameter. The circuit provides closed-loop control of the tip temperature and also permits it to be...

Differential scanning microcalorimetry of nuclei from cultured cells revealed differences between antitumor drugs in potency and mechanism. Scanning calorimetry of nuclei showed four structural transitions as the temperature was raised from 25 to 120 degrees C. Transitions II (76 degrees C), III (88 degrees C), and IV (105 degrees C), respectively, characterize the denaturation of the nucleosom...

OBJECTIVES To describe the use of sonication and microcalorimetry in diagnosing necrotizing fasciitis in a 27-year-old woman with bilateral breast implants. METHODS The removed breast implants were subjected to sonication and microcalorimetry. The microcalorimetry findings were correlated with conventional microbiologic methods. The time to detection of infection was noted. RESULTS The pati...

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

A novel formulation of cationic liposomes was studied by mixing dipalmitoylphosphatidylcholine (DPPC) with tetradecyltrimethylammonium bromide gemini surfactants different alkane spacer groups lengths attached to their ammonium head-groups. The physicochemical characterization the obtained combining experimental results from differential scanning microcalorimetry (DSC) molecular dynamic simulat...

The temperature dependences of the unfolding-refolding reaction of a shorter version of the alpha-spectrin SH3 domain (PWT) used as a reference and of two circular permutants (with different poly-Gly loop lengths at the newly created fused loop) have been measured by differential scanning microcalorimetry and stopped-flow kinetics, to characterize the thermodynamic nature of the transition and ...