Differential pulse polarography study was used to investigate the influence of glutathion on cis- and trans-DDP induced alterations of DNA structure. Though the applied concentration of glutathion has no effect on the reaction on DNA with cis-DDP, it greatly modifies the reaction with trans isomer. This may be an important reason for the ineffectiveness of the trans-DDP as an antitumor drug.

Catalytic currents yielded by cytochrome c in ammoniacal buffers containing cobalt ions at a dropping mercury electrode (Brdicka's catalytic currents) were investigated by means of direct current, differential pulse, normal pulse (NP) and phase-selective alternating current polarography. It was found that Brdicka's catalytic current of cytochrome c, (the more negative part of Brdicka's double w...

A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantificati...

Transition of single-stranded poly(A) into its double-helical protonated form was followed by means of derivative pulse polarography, spectrophotometry, and other methods. It was found that properties of protonated poly(A) depended on the length of single strands from which the protonated double helix was formed. In contrary to longer poly(A) transition of short single-stranded molecules (s(20)...

A simple and rapid differential pulse polarographic method was developed for the trace determination of azathioprine. A welldefined polarogram with three peaks was obtained in acetate buffer (pH 5.0) with peak potentials -0.27 V, -0.73 V and -1.02 V. The current-concentration linearity was found extend up to 5 x 10 mol L (r = 0.9992) with minimum detection limit of 2.8x10 mol L. The values of r...