Among the factors involved in the accumulation of citrate by a tissue following the injection of fluoroacetate in viva is the ability of the tissue to convert precursors into 4-carbon acids (1). An indirect measure of the importance of this conversion was reported in a recent study (2) in which the Krebs cycle was blocked both by fluoroacetate and malonate, but in this study concurrent analyses...

Malonate has long been regarded as a specific inhibitor for succinic dehydrogenase. The original evidence was obtained in Thunberg experiments with resting bacterial cultures (1, 2), and similar results were later obtained manometrically with brain and muscle tissue (3). The apparent specificity of this inhibition has led workers to use respiration experiments with malonate as a basis for theor...

It was previously shown that oxygen uptake per mole of substrate, using resting cell suspensions of a strain of Pseudomonas fluorescens, was significantly higher on malonate than on acetate (Wolfe and Rittenberg, 1953). If malonate is anaerobically decarboxylated to carbon dioxide and acetate, one would expect comparable oxygen consumption on the two substrates. The observed difference in uptak...

Background: For understanding the roles of fatty acids on the induction of acrosome reaction which occurs under association of cholesterol efflux and PKA or PKC pathways in boar spermatozoa, metabolic fate of alone and combined radiolabeled 14C-oleic acid and 3H-linoleic acid incorporated in the sperm was compared, and behavior of cholesterol and effects of PKA and PKC inhibitors upon fatty aci...

DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl[2-14C] acetate as part of a 6-step sequence.

Previously, we have reported that intranigral infusions of malonate, an inhibitor of mitochondrial function, lead to the degeneration of the dopaminergic neurons of the nigrostriatal pathway that is mediated, at least in part, through NMDA receptor activation and nitric oxide formation. In the present study, unilateral focal infusions of malonate into the nucleus basalis magnocellularis (nbM) o...

The title compound, [Dy(2)(C(3)H(2)O(4))(3)(H(2)O)(6)](n), forms a coordination polymeric structure comprising hydrated dysprosium ions and malonate ligands. In the asymmetric unit, there are one dysprosium ion, one and a half malonate ligands, and three water mol-ecules. Each Dy(III) atom is coordinated by six O atoms from four malonate ligands and by three water mol-ecules, and displays a tri...

Interest in malonic acid has been largely directed towards its role as a competitive inhibitor of succinic dehydrogenase. Very little attention has been directed toward the occurrence of malonic acid in plants or toward the metabolismi of malonic acid per se. Bentley ( 1 ) recently showed malonate to be present in some 18 species of legumes, one of which had concentrations as high as 2 mg/g dry...

The rate of O(2) uptake by sub-apical corn roots is largely resistant to 0.1 m Na-malonate at pH 5.0. The resistance of this tissue, in which the tricarboxylic acid cycle is very active, is not due to the compensatory induction of another oxidative pathway as seems to be the case in fresh potato slices. In corn roots malonate inhibits succinate utilization as expected and the smallness of the e...