We investigated the mode of signalling between mitochondria during apoptosis by monitoring the behaviour of non-irradiated mitochondria following microscopic photosensitisation of half the mitochondria in single human osteosarcoma cells loaded with CMXRos. Following partial irradiation of cells, non-irradiated mitochondria underwent a rapid depolarisation (within 10 minutes). The depolarisation...

In normal pancreatic acinar cells, the oxidant menadione evokes repetitive cytosolic Ca(2+) spikes, partial mitochondrial depolarisation, cytochrome c release and apoptosis. The physiological agonists acetylcholine and cholecystokinin also evoke cytosolic Ca(2+) spikes but do not depolarise mitochondria and fail to induce apoptosis. Ca(2+) spikes induced by low agonist concentrations are confin...

Multifocal motor neuropathy is a unique disease that not only challenges the electromyographer to make differential diagnosis from a fatal disease but also provides an opportunity to reconsider the mechanism of conduction block in demyelinating neuropathies. Conduction block or slowing is not always a consequence of demyelination, but can be due to membrane hyperpolarisation or depolarisation, ...

SUMMARY Hipoxia, hipercapnia and pH are known to activate the chemoreceptor cell of the carotid body by inducing membrane depolarisation. It is widely accepted that stimulus-induced depolarisation is due to the inhibition of K + currents. Besides these kation currents that undoubtfully play significant role in the chemotransduction process, chemoreceptor cells also possess anion currents, which...

Action potentials are mediated by transient changes in ion conductance across the cell surface membrane. These changes in conductance are primarily mediated by ion channels. Ion channels are membrane-embedded proteins that selectively pass specific ions upon opening. Some ion channels are constitutively open; however, most channels open following stimulation, such as through voltage changes, in...

the oil-paper insulation is a type of an inexpensive combination insulation system in oil-filled power transformers. in this study the dielectric and strength properties of canola oil and mineral oil impregnated hand-sheet papers were investigated. all hand sheets were made of unbleached bagasse soda pulp with two different freeness levels of 200 ± 25 ml, csf and 400± 25 ml,csf. after drying th...

We have previously shown that injection of anti-glycoprotein (GP) IIb induces murine immune thrombocytopenia (ITP) and that intravenous immunoglobulin (IVIg) ameliorates ITP. We hypothesise that murine ITP may be associated with platelet apoptosis, which is upregulated by anti-GPIIb and downregulated by IVIg. The current study demonstrated that anti-GPIIb injection induced three critical apopto...