نتایج جستجو برای: dicer1 protein

تعداد نتایج: 1235057  

2012
Jonathan Ip Paul Canham K. H. Andy Choo Yoshimi Inaba Shelley A. Jacobs Paul Kalitsis Deidre M. Mattiske Jane Ng Richard Saffery Nicholas C. Wong Lee H. Wong Jeffrey R. Mann

Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated that the reduced methylation is an indirect effect: the loss of Mir290 cluster miRNAs leads to upregulation of the transcriptional repressor RBL2 that...

Journal: :Journal of medical genetics 2012
Nelly Sabbaghian Nancy Hamel Archana Srivastava Steffen Albrecht John R Priest William D Foulkes

Pineoblastomas occur in RB-1 mutation carriers, but are rarely seen in association with other hereditary syndromes. Germline DICER1 mutations are associated with embryonal tumours such as pleuropulmonary blastoma (PPB), 4 so we hypothesised that such mutations might also occur in children with pineoblastoma. Here we describe a novel deleterious germline DICER1 mutation in a young child with a h...

Journal: :International journal of oncology 2013
Ying Bai Guang-Rong Qiu Fan Zhou Li-Ying Gong Feng Gao Kai-Lai Sun

Dicer, a member of the RNase III family, is the key enzyme required for the biogenesis of microRNAs and small interfering RNAs. Recent evidence indicates that DICER1 expression levels vary among different solid tumors and decreased or increased DICER1 expression has been associated with aggressive cancers. In this study, we assessed DICER1 expression levels in acute myeloid leukemia (AML) and i...

2015
Yemin Wang Jiamin Chen Winnie Yang Fan Mo Janine Senz Damian Yap Michael S. Anglesio Blake Gilks Gregg B. Morin David G. Huntsman

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, a rare class of sex-cord stromal cell tumors in young women. These hotspot mutations lost IIIb cleavage activi...

Journal: :Blood 2012
Dwayne L Barber

Gene targeting studies revealed that Dicer1 is required for murine embryogenesis.In this issue of Blood, Alemdehy and colleagues examine deletion of Dicer1 in myeloid progenitor cells using a conditional Cebpa-Cre allele. They show that deletion of Dicer1 is required for viability and that Dicer1 regulates steps of neutrophil maturation.

Journal: :Molecular and cellular endocrinology 2010
Lei Lei Shiying Jin Gabriel Gonzalez Richard R Behringer Teresa K Woodruff

Dicer is the ribonuclease III for synthesis of mature functional microRNAs (miRNAs), which play an important role in regulating cell development. In the mouse ovary, the Dicer1 protein was expressed in both oocyte and granulosa cells of the follicle. In the present study, the role of miRNAs in mouse ovarian development was explored by using Dicer1 conditional knockout (cKO) mouse ovarian tissue...

Journal: :Journal of medical genetics 2011
Ingrid Slade Chiara Bacchelli Helen Davies Anne Murray Fatemeh Abbaszadeh Sandra Hanks Rita Barfoot Amos Burke Julia Chisholm Martin Hewitt Helen Jenkinson Derek King Bruce Morland Barry Pizer Katrina Prescott Anand Saggar Lucy Side Heidi Traunecker Sucheta Vaidya Paul Ward P Andrew Futreal Gordan Vujanic Andrew G Nicholson Neil Sebire Clare Turnbull John R Priest Kathryn Pritchard-Jones Richard Houlston Charles Stiller Michael R Stratton Jenny Douglas Nazneen Rahman

BACKGROUND Constitutional DICER1 mutations were recently reported to cause familial pleuropulmonary blastoma (PPB). AIM To investigate the contribution and phenotypic spectrum of constitutional and somatic DICER1 mutations to cancer. METHODS AND RESULTS The authors sequenced DICER1 in constitutional DNA from 823 unrelated patients with a variety of tumours and in 781 cancer cell lines. Cons...

2014
Céline Zimmermann Yannick Romero Maria Warnefors Adem Bilican Christelle Borel Lee B. Smith Noora Kotaja Henrik Kaessmann Serge Nef Helen White-Cooper

Small non-coding RNAs act as critical regulators of gene expression and are essential for male germ cell development and spermatogenesis. Previously, we showed that germ cell-specific inactivation of Dicer1, an endonuclease essential for the biogenesis of micro-RNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), led to complete male infertility due to alterations in meiotic progr...

2015
Ida Björkgren Petra Sipilä

Dicer1 is an RNase III enzyme necessary for microRNA (miRNA) biogenesis, as it cleaves pre-miRNAs into mature miRNAs. miRNAs are important regulators of gene expression. In recent years, several miRNA-independent roles of Dicer1 have been identified. They include the production of endogenous small interfering RNAs, detoxifying retrotransposon-derived transcripts, and binding to new targets; mes...

2015
Naoki Nakagawa Cuiyan Xin Allie M. Roach Natalie Naiman Stuart J. Shankland Giovanni Ligresti Shuyu Ren Suzanne Szak Ivan G. Gomez Jeremy S. Duffield

MicroRNAs, activated by the enzyme Dicer1, control post-transcriptional gene expression. Dicer1 has important roles in the epithelium during nephrogenesis, but its function in stromal cells during kidney development is unknown. To study this, we inactivated Dicer1 in renal stromal cells. This resulted in hypoplastic kidneys, abnormal differentiation of the nephron tubule and vasculature, and pe...

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