Yacon is a perennial plant originating from the Andean region whose roots have been receiving increased attention due to their high content of prebiotic fructooligosaccharides (FOS). Apart from many health benefits, FOS have interesting characteristics as food ingredients, so are used as sugar substitute, and their extraction from yacon roots may be an alternative to commercially available FOS....

The purification of virus particles and viral vectors for vaccine and gene therapy applications is gaining increasing importance in order to deliver a fast, efficient, and reliable production process. Ultrafiltration (UF) is a widely employed unit operation in bioprocessing and its use is present in several steps of the downstream purification train of biopharmaceuticals. However, to date few s...

Monoclonal antibodies (mAbs) are one of the fastest growing drug molecules targeting the treatment of diseases ranging from arthritis, immune disorders, and infectious diseases to cancer. Due to its unique application principle, antibodies are commonly produced in large quantities. Plants, such as Nicotiana benthamiana, offer a unique production platform for bio-therapeutics due to their abilit...

In this paper, we deal with the model-based time-optimal operation of a batch diafiltration process in the presence of membrane fouling. Membrane fouling poses one of the major problems in the field of membrane processes. We model the fouling behavior and estimate its parameters using various methods. Least-squares, least-squares with a moving horizon, recursive least-squares methods and the ex...