We have developed a method to isolate insulin-responsive human hepatocytes from an intraoperative liver biopsy to study insulin action and resistance in man. Hepatocytes from obese patients with noninsulin-dependent diabetes were resistant to maximal insulin concentration, and those from obese controls to submaximal insulin concentration in comparison to nonobese controls. Insulin binding per c...

Leptin is the protein product of the ob gene, an adipocyte-specific gene, recently discovered in mice. Plasma leptin levels were determined in six normals, twenty-one subjects with impaired glucose tolerance, and forty-nine untreated NIDDM subjects. They increased with the augmentation of obesity (body mass index, BMI kg/m2) and were higher in females than in males: in BMI less than 25 kg/m2 th...

Obesity is common in non-insulin-dependent diabetes mellitus (NIDDM) patients; in Singapore in a cohort of 314 diabetics, 44.3% were overweight. Management of obesity in diabetics differs from that in non-diabetics in that it is more urgent; weight maintenance is more difficult and hypoglycaemic medication may cause weight changes. However, like in the non-diabetic, management of obesity in the...

OBJECTIVE To determine serum resistin levels in obese patients with diabetes mellitus type II. METHODS We studied 87 subjects in an sectional study, divided into 3 groups: obese, obese diabetic and normal subjects. Their age, gender and body mass index were recorded. Serum resistin, insulin, glucose, cholesterol, high-density lipoproteins, low-density lipoproteins, triglyceride, urea and crea...

Background: The earliest detectable abnormality in diabetes mellitus type II (DM II) is the impairment of body’s ability to respond to insulin, necessitating extra insulin secretion in an attempt to stimulate the desensitized cells. Obesity is considered as the single most important, reversible, causative environmental factor for insulin resistance (IR) aggravating the metabolic disturbance in ...

This study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients we...

Tissue sensitivity to exogenous insulin was determined in 10 obese diabetic patients, in 15 patients with simple obesity, and in 28 non·obese controls. Eight of the obese diabetics and five of the patients with simple obesity underwent dietary restriction (1,000-1,600 kcal/day) and physical training for eight weeks. Insulin sensitivity was evaluated by the euglycemic insulin clamp technique for...

Objective: To identify the high risk group for developing obesity among a cohort of Saudi diabetic patients. Methods: A cross sectional study on a random sample of known type 2 diabetic patients who were visiting seven primary health care centers in Jeddah, Saudi Arabia was conducted. Participants were categorized according to their Body Mass Index BMI into 4 groups. Prevalence of obesity was c...