objective: atorvastatin has the pleiotropic effects, including anti-inflammation and antioxidant. therefore, this study considered to examine the effects of atorvastatin on nf-қb expression, as a main transcription factor for expression of inflammatory cytokines, in hyperglycemia-induced nephropathy in rat. materials and methods: twenty four male wistar rats were randomly divided into four grou...

background neuropathy is one of the most complications of diabetes that may be associated with changes in the structure and function of the basement membranes in nerves. laminin is one of the most important components of basement membranes in sciatic nerve. objectives in this study, the protective effects of alpha lipoic acid (ala) as an antioxidant agent on blood glucose level, body weight and...

objective(s): diabetes mellitus is a public health problem and one of the five leading causes of death globally. in the present study, the effect of metformin with natural honey was investigated on glycemia in the streptozotocin-induced diabetic rats. materials and methods: thirty wistar male rats were randomly divided into six groups including c: non ­diabetic rats received distilled water, ch...

introduction: vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify immunohistochemical changes that occur in the pancreatic beta ([pancreatic islet beta]) cells of vanadyl sulphate (vs) treated stz induced diabetic rats. materials and methods: male wistar rats were made diabetic with injecting a single intr...

background: royal jelly has been shown to have antioxidant and antidiabetic effects. the objective of this study was to evaluate the protective effect of rj against kidney damage in streptozotocin induced diabetic rats. methods: thirty two male wistar rats were divided randomly into four groups (n=8 per group). normal control and diabetic control groups received 1cc/day distilled water, normal ...

the aim of the present study was to evaluate the effect of melatonin as an antioxidant on spatial navigation memory in male diabetic rats. thirty-two male white wistar rats weighing 200 ± 20 g were divided into four groups, randomly: control, melatonin, diabetic and melatonin-treated diabetic. experimental diabetes was induced by intraperitoneal injection of 50 mg kg-1 streptozotocin. melatonin...

objective: the effect of herbal medicine is more useful than synthetic medicines. the present research paper aims to show the effects of leaves extracts of zizyphus spina christi (zsc) on lipid profile, lipid peroxidation and activities of aminotransferase enzymes in streptozocin induced diabetic adult male rats. materials and methods: fifty six male rats weighing 150-200 gm were included in th...

introduction: aim of present research was to review the effect of resistance training on glycemic indexes of streptozotocin induced diabetic rats. methods: for this purpose 36 male rats with weight 308/82±29/57 selected. one week after induction of diabetes diabetic rats were randomly divided into two groups including resistance training and control and healthy rats divided in to two groups inc...

background apoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. it has been indicated that some opium derivatives develop cell apoptosis. objectives the aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic wistar rats. materials and methods this experime...

background and objective: diabetes mellitus is common endocrine disease cause learning and memory impairment. this study was done to evaluate the effect of quercetin on learning and memory in stz-induced diabetic rats was investigated. methods: in this experimental study, 40 male wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin -...