Introduction: Some studies show magnesium has anticonvulsive effect in some animal models. Despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nMgO). According to the interaction between magnesium and convulsion, this study was designed to evaluate the effect of nMgO on strychnine-i...

objective: arctium lappa (burdock), (a. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. this study was conducted to evaluate the antidiabetic and hypolipidemic properties of a. lappa root extract on nicotinamide-streptozotocin (na-stz)-induced type2 diabetes in mice.materials and methods: in this investigation, 70 adult ...

Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic extract of Urtica dioica and pioglitazone (PIO) on the prevention of DN in streptozotocin induced-diabetic mice. Materials and Methods: Forty-two mice were divided into six groups as follows: non-...

Background and objectives:Diabetes is the most common metabolic disorder with severe effects on quality of life. Decreasing serum glucose levels and normalization of kidney parameters is of great clinical importance for treating diabetes. Urtica dioica L. has been used in as anti-inflammatory, antioxidant, anti-fungal, and antibacterial agent. To our knowledge, there a...

This study investigated the effect of nicotinamide (NAM) supplementation on development brain inflammation and microglial activation in a mouse model type 1 diabetes mellitus. C57BL/6J male mice, which were made diabetic with five consecutive, low-dose (55 mg/kg i.p.) streptozotocin (STZ) injections. Diabetic mice randomly distributed different experimental groups challenged to doses NAM (untre...

Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...

Background and objectives: Due to the rapid growth of global interest in use of ethno medicinal plants, their effects and safety assessment have become substantial. Gundelia tournefortii has been used as antioxidant, anti-inflammatory, antipyretic, anti-fungal, and antibacterial agent. In the present study, nephrprotective and antidiabetic properties of Gundelia to...

patients afflicted by diabetes mellitus (dm) usually have more infections than those without dm. the course of the infections is also more complicated in this group of patients. one of the possible causes of increased infections prevalence is a deficiency in the immunity. besides some decreased cellular responses in vitro, no disturbances in adaptive immunity in diabetic patients have been desc...

Introduction: There is evidence that diabetes affects seizure susceptibility. Ginger (Zingiber officinale Roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. The aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (PTZ) in diabetic mice after induction of diabetes with streptozocin and to examine the possible ...

noise is considered as one of the harmful factors at industrial environments. it affects human health in different aspects including harmful influences on auditory, vision, neurological and psychiatric systems, hormones, physiological and mental systems. paying attention to the importance of hormonal effects on human body seems to possess crucial importance. the aim of the present study is to i...