Background: There is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. This study aimed at determining the anti-apoptotic effect of Oleuropein (Ole) on dexamethasone-induced apoptosis of mouse thymocytes. Method: Mice ...

Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...

conclusions ptps is a common problem following cabg, and pre-emptive therapy with dex may decrease neuropathic pain. results fifty-four patients were placed in the control group, and 50 patients were assigned to the dex group. the age, sex, and body mass index were not significantly different between the two groups of study (p > 0.05). the incidence of ptps was 11/50 (22%) patients in the dex g...

Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...

Recently, electrospinning technology has been widely used as a processing method to make nanofiber sheets (NS) for biomedical applications because of its unique features, such as ease of fabrication and high surface area. To develop a sustained dexamethasone (Dex) delivery system, in this work, poly(ε-caprolactone-co-l-lactide) (PCLA) copolymer with controllable biodegradability was synthesized...

oxidative stress is one of the important mechanisms involved in dexamethasone (dex)-induced hypertension. protocatechuic acid (pca) is a natural compound with high antioxidant capacity. in this investigation, the effect of pretreatment with pca was studied in dex-induced hypertensive male wistar rats. for induction of hypertension, dex was injected subcutaneously for 14 days. pca (50, 100 and 2...

Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of patient’s teeth were cultured with Dex (0....

ferula foetida (bunge) regel. is one of the most widespread and important ferula species with nutritional and medicinal applications. some phytochemicals with helpful cardiovascular effects have been isolated from ferula species. the present study was designed to evaluate the effects of hydroalcoholic extract of the stems of f. foetida in dexamethasone (dex)-induced hypertension in rats. hypert...

background dox is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. however, its cardiac toxicity limits the clinical usefulness of this drug. previous reports have shown corticosteroids induce a cytoprotective effect on cardiomyocytes. mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for as...

Oxidative stress is one of the important mechanisms involved in Dexamethasone (Dex)-induced hypertension. Protocatechuic acid (PCA) is a natural compound with high antioxidant capacity. In this investigation, the effect of pretreatment with PCA was studied in Dex-induced hypertensive male Wistar rats. For induction of hypertension, Dex was injected subcutaneously for 14 days. PCA (50, 100 and 2...