Microorganisms are involved in all elemental cycles and therefore it is important to study their metabolism in the natural environment. A recent technique to investigate this is the hydrogen isotopic composition of microbial fatty acids, i.e., heterotrophic microorganisms produce fatty acids enriched in deuterium (D) while photoautotrophic and chemoautotrophic microorganisms produce fatty acids...

هدف از این مطالعه بررسی اثر آب تهی شده دوتریم (DDW) در غلظت­های مشخص بر روی سلول­های 29HT- و 480SW- بود. رده­های سلولی محیط RPMI حاوی مختلف DDW به مدت 24، 48 72 ساعت کشت داده شدند سپس درصد بقای روش سنجش سمیت مبتنی برMTT تعیین شد. یافته­ها نقش توأم کاهش افزایش زمان تیمار را مهار رشد اثبات رساند. کم­ترین میزان برای طی با غلظت ppm 30 ترتیب 23% 37% دست آمد. جهت اثرات جانبی دوتریم، طبیعی 12C2C نیز ت...

The effects of deuterium-depleted water (DDW) containing deuterium (D) at a concentration 25 parts per million (ppm), 50 ppm, 105 ppm and the control 150 were monitored in MIA-PaCa-2 pancreatic cancer cells by real-time cell impedance detection xCELLigence method. data revealed that lower concentrations corresponded to MiA PaCa-2 growth rate. Nuclear membrane turnover nucleic acid synthesis rat...

Heart failure results from the loss of structural integrity heart and/or a decrease in rate maximal ATP production. In cases relatively preserved integrity, production mitochondria leads to cardiac stroke volume, thereby increasing required maintain output. For many years, exact location this defect metabolic energy cycle remained elusive. Evidence is presented here show that it not single subs...

Non-small cell lung cancer (NSCLC) is the most common type of cancer, accounting for 84% all diagnoses. In advanced NSCLC, including adenocarcinoma and squamous carcinoma, median survival time (MST) rarely exceeds 10-12 months. Reduced deuterium (D) concentration in water tissue culture media drinking humans has shown a strong anticancer effect previous investigations. present study, 1 parts pe...