نتایج جستجو برای: destruction mechanism
تعداد نتایج: 598495 فیلتر نتایج به سال:
Bone destruction is a hallmark of myeloma and affects 80% of patients. Myeloma cells promote bone destruction by activating osteoclasts. In investigating the underlying mechanism, we found that C-reactive protein (CRP), a protein secreted in increased amounts by hepatocytes in response to myeloma-derived cytokines, activated myeloma cells to promote osteoclastogenesis and bone destruction in vi...
Eukaryotic cell cycle transitions are driven by E3 ubiquitin ligases that catalyze the ubiquitylation and destruction of specific protein targets. For example, the anaphasepromoting complex/cyclosome (APC/C) promotes the exit from mitosis via destruction of securin and mitotic cyclins, whereas CRL1 allows entry into S phase by targeting the destruction of the cyclin-dependent kinase (CDK) inhib...
Sitting in our offices early in the morning of September 11, 2001, we, like many across the world, watched with incredulity the twin terrorist strikes on the World Trade Centre. Riveted to the television screen, we witnessed the beginnings of a nightmare whose images will likely remain with us for a long time. September 11, and the events that followed, changed our assumptions of world terroris...
Since the late 1970s, Libyan leader Colonel Muammar Qadhafi has sought to obtain weapons of mass destruction (WMD), particularly chemical and biological weapons (CBW). By the late 1980s, Libya had developed a rudimentary capability to produce such weapons. Western experts view the pursuit of CBW as a means of bolstering Libya’s military capability, since the country lacks effective conventional...
Uncertainty about behavior: Uncertainty about behavior refers to uncertainty regarding the actions taken by others. Sometimes it is hard to know what other states are doing – in particular, if they are cooperating or defecting. Consider weapons of mass destruction. Whatever a state may say publicly, it is very difficult for others to ascertain whether it is pursuing technologies associated with...
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