This study examined seasonal changes in indoor Dermatophagoides pteronyssinus 1 (Der p 1)/Blattella germanica 1 (Bla g 1) antigen concentrations in the homes of atopic asthmatic and atopic nonasthmatic children. Possible associations between environmental allergen exposure and levels of exhaled breath indices were also evaluated.A total of 38 atopic children were recruited for this cross-sectio...

BACKGROUND Carpets are large reservoirs of the dust mite allergen Der p 1. The effect of vacuum cleaning on the distribution of Der p 1 in carpets is poorly understood. METHODS Samples were cut from 7 used household carpets, all over 5 years of age. From each carpet, 10 samples were left untreated, 10 vacuumed with an upright vacuum cleaner, and 10 vacuumed with a canister vacuum cleaner. Eac...

The modulations of β-catenin were analyzed during the inflammatory response induced by the Der p 1 house dust mite allergen. Der p 1 induced the dose-dependent expression of inflammatory cytokines, including interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α) in THP-1 human monocytic cells. The mRNA expression levels of β-catenin were not alt...

A cDNA clone coding for the major house dust mite allergen Der p 1 was isolated from a lambda gt 11 library. Its sequence correlates with known amino acid sequences of Der p 1 and it produces a fusion protein which reacts with rabbit anti-Der p 1 antiserum.

REFERENCES 1. London, 1964. Two recent German works elaborate on some aspects of this theme: SCHOENER, ERICH, Das Viererschema in der antiken Humoralpathologie, Wiesbaden, 1964 (Supplement 4, Sudhoffs Arch. Gesch. Med. Naturw.), and FLAswA1R, HELMUT, Melancholie und Melancholiker in den medizinischen Theorien der Antike, Berlin, 1966. 2. SCHOENR, Op. cit., p. 102. 3. Ibid., p. 56. 4. RIBBRT, Mo...

House dust mites produce inhalant allergens of importance to allergic patients. We measured the major group 1 allergens, Der p 1 and Der f 1, from the house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farina, respectively in 100 randomly selected domestic homes from Cheonan, Korea. Dust samples were collected by vacuuming from the living room floor and 1 mattress in each home...

BACKGROUND The role of mite allergen exposure in sensitization and development of asthma has been widely recognized. Previous studies have shown that Dermatophagoides pteronyssinus and Blomia tropicalis were the most prevalent house dust mites in Brazil, while D. farinae was rarely found. The aim of this study was to measure Der f 1 and Der p 1 allergen levels in Brazilian asthmatics' and contr...

The aim of this study was to determine the level of two major mite allergens Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1) in 30 urban homes in Zagreb, Croatia, using the enzyme immunoassay with two monoclonal antibodies which has been established as the reference method for indoor allergen analysis. Dust samples were taken by vacuuming a carpeted area and coll...