Objectives: The study aimed at testing the existence of interpretative bias in remitted depressives as compared to unipolar depressives and never-depressed individuals. Method: Cognitive Bias Questionnaire was administered on 10 individuals each with unipolar depression, remitted depression, and never-depressed participants. Participants were presented with vague and ambiguous vignettes of pote...

Blood copper, zinc, magnesium and lead levels were determined by atomic absorption spectroscopy for 15 males and 16 females suffering from depression, 6 males and 1 female with mental retardation and 3 males and 4 females with seizure disorders. They were all under no medication and belonged to low income groups. No difference in copper levels was found between the sexes in any of the groups. T...

Dipeptidyl peptidase IV (DPPIV) and adenosine deaminase (ADA), two T cell associated enzymes, are known to have a possible interaction and play essential roles in immune system functioning. On the other hand, depression has been shown to be accompanied with some immune-inflammatory alterations. In this regard, in order to make a contribution to the understanding of the ongoing immune disturbanc...

BACKGROUND The serotonin-1A (5HT1A) receptor system has been implicated in the pathophysiology of major depression by postmortem studies of suicide victims and depressed subjects dying of natural causes. This literature is in disagreement, however, regarding the brain regions where 5HT1A receptor binding differs between depressives and controls and the direction of such differences relative to ...

Disinhibited activity of the hypothalamic-pituitary-adrenocortical (HPA) neuroendocrine system, characterized most specifically by abnormal responses to the dexamethasone suppression test (DST), is observed in 40-50% of patients with endogenous depression. The heterogeneity of endogenous depressives with respect to this neuroendocrine marker is so far unexplained. A recent report from Iowa sugg...

Out of 88 cases of depression, admitted in Department of Psychiatry, K.G's. Medical College, Lucknow, 33 cases fulfilling the inclusion criteria were assessed for severity of depression and memory performance and were compared with memory scores of normal healthy controls. After treatment with drugs, improved depressives served as their own controls also. Memory scores of depressives were found...

Thirty patients of Major Depressive Disorder, Schizophrenia and normal healthy controls each, received an overnight dexamethasone suppression test. Plasma and urinary Cortisol measurements showed that depressed patients had increased adrenocortical activity before dexamethasone and they showed an abnormal early escape from suppression which had a relationship with severity of depression. An att...

This study examines the differences between the prevalence of negative symptoms in schizophrenia and Major depression, diagnosed according to RDC, using Andreasen's Scale for Assessment of Negative Symptoms, SANS. Global ratings of affective flattening, alogia, avolition and inattention were significantly higher in schizophrenics whereas anhedonia - asociality were seen as commonly in depressiv...

The presence and absence of the feelings of guilt and hostility in depression had been a matter of controversy in the cross-cultural literature. In the psychopathology of depression, these feelings have been considered playing a significant role. Redlich and Freedman (1966) reported that the feelings of guilt in depressive patients were found to be associated with shame as well as unworthiness ...

Forty elderly psychiatric out-patients with an ICD-9 diagnosis of depression and twenty matched controls were studied for the presence of physical illnesses, using a pre-defined battery of investigative techniques. While the prevalence of physical illness diagnosis was not significantly different between the two groups, the number of subjects with undiagnosed illnesses and those with multiple i...