Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of sm...

This study focuses on the transient and dynamic activation of intracellular signal transduction following different protocols of depolarization. During chronic depolarization, phosphorylation of extracellular signal-regulated kinases (ERKs) was observed to peak and subsequently fall to low levels within 10 min of depolarization. Short periods of depolarization, from 1 to 5 min in duration, also...

Multi-frequency radio polarimetric observations of the diffuse Galactic synchrotron background enable us to study the structure of the diffuse ionized gas via rotation measure maps. However, depolarization will introduce artifacts in the resulting rotation measure, most notably in the form of narrow, elongated “depolarization canals”. We use numerical models of a non-emitting Faraday rotating m...

Flavor-dependent neutrino emission is critical to the evolution of a supernova and its signal. In dense anisotropic interior star, neutrino-neutrino forward scattering can lead fast collective oscillations, which has striking consequences. We present theory flavor depolarization, explaining how differences become smaller, i.e., depolarize, due diffusion smaller angular scales. show that transve...

Abstract Microglia react to danger signals by rapid and targeted extension of cellular processes towards the source signal. This positive chemotactic response is accompanied a hyperpolarization microglia membrane. Here, we show that optogenetic depolarization has little effect on baseline motility, but significantly slows down response. Reducing extracellular Ca 2+ concentration mimics depolari...

ADIFFERENCE has been observed in certain instances between the onset of QRS in intracavitary and surface limb leads. Simultaneous tracings demonstrate that when premature ventricular depolarization exists the early rapid growth in magnitude of potential recorded by intracavitary leads may be nearly or totally inapparent in surface leads. Following premature depolarization changes occur in intra...

Abstract This chapter is a general introduction to spin dynamics in beam lines and accelerators, resonant depolarization cyclic accelerators.

A defining property of L-type Ca(2+) channels is their potentiation by both 1,4-dihydropyridine agonists and strong depolarization. In contrast, non-L-type channels are potentiated by neither agonist nor depolarization, suggesting that these two processes may by linked. In this study, we have tested whether the mechanisms of agonist- and depolarization-induced potentiation in the cardiac L-type...