Biotite and K-feldspar Ar/Ar systems from the east-central Peninsular Ranges batholith near 33°N were affected by two distinct phases of Late Cretaceous rapid cooling. The 85-Ma biotite K-Ar isochron separates comparatively shallow rocks in the southwest that record earlier cooling (91–86 Ma) from deeper rocks in the northeast that record later cooling (78–68 Ma). Samples close to 85 Ma isochro...

Many biogeochemical and Earth surface processes depend critically on chemical weathering. The immediate products of chemical weathering are present as solutes and secondary minerals in groundwater, soils, and streams, and form the nutritional foundation for terrestrial biogeochemistry. Chemical weathering also contributes to physical erosion by weakening bedrock and producing easily erodible re...

We define uplift and denudation, then review the basic principles underlying the mechanisms for producing uplift, and the methodologies used to quantify the geological timescale denudation history of uplifted regions. Uplift is represents work done against gravity, and does not necessarily lead immediately to rapid denudation. The causes of uplift can be categorised according to the principal d...

The study of a sample of river sediment enables the determination of spatially averaged denudation rates that provide an exceptional perspective on erosion and weathering processes that have taken place within a landscape. These measurements are done with in-situ produced cosmogenic nuclides (e.g. Be, Al), mostly in quartz from alluvial sediment. Cosmogenic nuclides are produced when secondary ...

Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical denudation. Two VEGF tyrosine kinase receptors have been reported-fms-like-tyrosine kinase-1 (Flt-1) and kinase domain region (KDR). Little is known about the regulation of the expression of these receptors after vascular injury. Herein, we have an...

Using electron microscopy, we investigated the small arteries and veins in ischemic lesions induced by occlusion of the ostium of the middle cerebral artery in 42 rats. We observed endothelial denudation in the small arteries of rats receiving occlusion for greater than 6 hours. When the occluding cylinder was removed to allow for reperfusion, however, 2 hours of occlusion was sufficient for en...