نتایج جستجو برای: dense granule antigen
تعداد نتایج: 292316 فیلتر نتایج به سال:
Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of alpha-granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and serotonin) on cryosections of human megakaryocy...
Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open canalicular system. Yet, the influence of the actin cytoskeleton in controllin...
Non-hydrolyzable GTP analogues, such as guanosine 5'-(beta, gamma-imido)triphosphate (GppNHp), induce granule secretion from permeabilized platelets in the absence of increased intracellular Ca(2+). Here, we show that the GppNHp-induced dense granule secretion from permeabilized platelets occurred concomitantly with the activation of small GTPase Ral. This secretion was inhibited by the additio...
Heritable granule deficiencies have enabled the identification of proteins involved in dense granule biogenesis. Yet how these proteins are organized into pathways to create dense granules has remained unknown due to a lack of adequate cellular models to study platelet granule trafficking. Ambrosio et al now describe such a cell model and provide an unprecedented glimpse into the birth of dense...
Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects Jacqueline Stockley, Neil V. Morgan, Danai Bem, Gillian C. Lowe, Marie Lordkipanidzé, Ban Dawood, Michael A. Simpson, Kirsty Macfarlane, Kevin Horner, Vincenzo C. Leo, Katherine Talks, Jayashree Motwani, Jonathan T. Wilde, Peter W. Collins, Michael Makris, Steve P. Watson, and...
cattle syndrome absent in MKs from CHS cattle at all stages of maturation. MKs in bone marrow samples from two control (n = 91) five and two CHS (n = 61 ) cattle that had been processed for were the uranaffin reaction were also evaluated. The clear microsvesicles were replaced by uranaffin-positive granules in in MKs from control cattle. but positive uranaffin granules clear were not observed i...
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.
Mepacrine uptake into platelets and bone marrow megakaryocytes was analyzed to further characterize the dense granule defects in a group of seven mouse pigment mutants that have characteristics of platelet storage pool disease (SPD). In contrast to our previous studies using electron microscopy, this method revealed that all mutants had normal numbers of dense granules. However, total mepacrine...
Samples of tissue from molluscum contagiosum lesions were fixed in 1 per cent buffered osmium tetroxide (1) for 3 hours, then washed in veronalacetate at pH 7.3 for 21/~ hours, dehydrated in graded alcohols, and embedded in methacrylate. Thin sections of this material were taken for study in the electron microscope. A small dense granule was found within the elementary bodies contained in these...
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