The osteogenic effect of bone marrow was tested in rabbits, using chambers that had been implanted in the peritoneal cavity (ectopic site) and in a delayed-union model (orthotopic site). Osteogenesis was accelerated in both sites after concentration of marrow elements by centrifugation, but not after unit gravity sedimentation. Chambers that were implanted with marrow that had been processed by...

Ex vivo gene therapy, utilizing modified fibroblasts that deliver BDNF or NT-3 to the acutely injured spinal cord, has been shown to elicit regeneration and recovery of function in the adult rat. Delayed grafting into the injured spinal cord is of great clinical interest as a model for treatment of chronic injury but may pose additional obstacles that are not present after acute injury, such as...

HYPOTHESIS Advances in burn treatment including early excision of the wound have increased survival in patients treated at specialized burn centers. We hypothesized that the patients with delayed wound excision and grafting would experience deleterious outcomes. METHODS From 1995 to 1999, 157 children with acute burns covering 40% or more of total body surface area and having more than 10% of...

Fournier’s gangrene (FG) is a fulminant and lethal condition usually occurring in the immunocompromised, first described 1883 by French dermatologist Jean Alfred Fournier. It form of necrotizing fasciitis perineal, genitourinary perianal regions mostly males with mortality nearly 20-50%. surgical emergency requires early diagnosis aided scores such as laboratory risk indicator for necrotising (...

The common problems seen in distal femoral fractures are communition, articular surface involvement, fractures in multiple planes and bone loss in compound fractures. They present a challenge to the surgeon to achieve stable fixation and union. With different methods of internal fixation available, the common complications encountered with distal femoral fractures are malunion, varus collapse, ...

This study compared bone grafting regimens and different implant surfaces used for sinus augmentation and presented long-term implant success rates in augmented sinuses. Two hundred fifty-seven consecutive patients with 625 implants were evaluated retrospectively. In phase 1, 188 sinuses were grafted with (1) autograft alone; (2) autograft + demineralized freeze-dried bone allograft (DFDBA) + a...

Forty cases of clear corneal grafts in 2 groups of patients who developed corneal opacities either before or after 5 years of age were investigated for the pattern of amblyopia and fixation. A severe irreversible form of amblyopia with eccentric fixation was observed in cases of unilateral corneal opacity when the anomaly occurred before the age of 5 years and corneal grafting was delayed until...